The human transcriptome map: Clustering of highly expressed genes in chromosomal domains

H. Caron; B. Van Schaik; M. Van der Mee; F. Baas; G. Riggins; P. Van Sluis; M. C. Hermus; R. Van Asperen; K. Boon; P. A. Voûte; S. Heisterkamp; A. Van Kampen; R. Versteeg

doi:10.1126/science.1056794

The human transcriptome map: Clustering of highly expressed genes in chromosomal domains

H. Caron, B. Van Schaik, M. Van der Mee, F. Baas, G. Riggins, P. Van Sluis, M. C. Hermus, R. Van Asperen, K. Boon, P. A. Voûte, S. Heisterkamp, A. Van Kampen, R. Versteeg

Research output: Contribution to journal › Article › peer-review

587 Scopus citations

Abstract

The chromosomal position of human genes is rapidly being established. We integrated these mapping data with genome-wide messenger RNA expression profiles as provided by SAGE (serial analysis of gene expression). Over 2.45 million SAGE transcript tags, including 160,000 tags of neuroblastomas, are presently known for 12 tissue types. We developed algorithms to assign these tags to UniGene clusters and their chromosomal position. The resulting Human Transcriptome Map generates gene expression profiles for any chromosomal region in 12 normal and pathologic tissue types. The map reveals a clustering of highly expressed genes to specific chromosomal regions. It provides a tool to search for genes that are overexpressed or silenced in cancer.

Original language	English (US)
Pages (from-to)	1289-1293
Number of pages	5
Journal	Science
Volume	291
Issue number	5507
DOIs	https://doi.org/10.1126/science.1056794
State	Published - Feb 16 2001
Externally published	Yes

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title = "The human transcriptome map: Clustering of highly expressed genes in chromosomal domains",

abstract = "The chromosomal position of human genes is rapidly being established. We integrated these mapping data with genome-wide messenger RNA expression profiles as provided by SAGE (serial analysis of gene expression). Over 2.45 million SAGE transcript tags, including 160,000 tags of neuroblastomas, are presently known for 12 tissue types. We developed algorithms to assign these tags to UniGene clusters and their chromosomal position. The resulting Human Transcriptome Map generates gene expression profiles for any chromosomal region in 12 normal and pathologic tissue types. The map reveals a clustering of highly expressed genes to specific chromosomal regions. It provides a tool to search for genes that are overexpressed or silenced in cancer.",

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AU - Caron, H.

AU - Van Schaik, B.

AU - Van der Mee, M.

AU - Baas, F.

AU - Riggins, G.

AU - Van Sluis, P.

AU - Hermus, M. C.

AU - Van Asperen, R.

AU - Boon, K.

AU - Voûte, P. A.

AU - Heisterkamp, S.

AU - Van Kampen, A.

AU - Versteeg, R.

PY - 2001/2/16

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AB - The chromosomal position of human genes is rapidly being established. We integrated these mapping data with genome-wide messenger RNA expression profiles as provided by SAGE (serial analysis of gene expression). Over 2.45 million SAGE transcript tags, including 160,000 tags of neuroblastomas, are presently known for 12 tissue types. We developed algorithms to assign these tags to UniGene clusters and their chromosomal position. The resulting Human Transcriptome Map generates gene expression profiles for any chromosomal region in 12 normal and pathologic tissue types. The map reveals a clustering of highly expressed genes to specific chromosomal regions. It provides a tool to search for genes that are overexpressed or silenced in cancer.

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The human transcriptome map: Clustering of highly expressed genes in chromosomal domains

Abstract

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