TY - JOUR
T1 - The Human Toxome Project
AU - Bouhifd, Mounir
AU - Andersen, Melvin E.
AU - Baghdikian, Christina
AU - Boekelheide, Kim
AU - Crofton, Kevin M.
AU - Fornace, Albert J.
AU - Kleensang, Andre
AU - Li, Henghong
AU - Livi, Carolina
AU - Maertens, Alexandra
AU - McMullen, Patrick D.
AU - Rosenberg, Michael
AU - Thomas, Russell
AU - Vantangoli, Marguerite
AU - Yager, James D.
AU - Zhao, Liang
AU - Hartung, Thomas
N1 - Publisher Copyright:
© 2015, Elsevier GmbH. All rights reserved.
PY - 2015
Y1 - 2015
N2 - The Human Toxome Project, funded as an NIH Transformative Research grant 2011-2016, is focused on developing the concepts and the means for deducing, validating and sharing molecular pathways of toxicity (PoT). Using the test case of estrogenic endocrine disruption, the responses of MCF-7 human breast cancer cells are being phenotyped by transcriptomics and mass-spectrometry-based metabolomics. The bioinformatics tools for PoT deduction represent a core deliverable. A number of challenges for quality and standardization of cell systems, omics technologies and bioinformatics are being addressed. In parallel, concepts for annotation, validation and sharing of PoT information, as well as their link to adverse outcomes, are being developed. A reasonably comprehensive public database of PoT, the Human Toxome Knowledge-base, could become a point of reference for toxicological research and regulatory test strategies. regulatory toxicology, safety sciences, transcriptomics, metabolomics, alternative methods.
AB - The Human Toxome Project, funded as an NIH Transformative Research grant 2011-2016, is focused on developing the concepts and the means for deducing, validating and sharing molecular pathways of toxicity (PoT). Using the test case of estrogenic endocrine disruption, the responses of MCF-7 human breast cancer cells are being phenotyped by transcriptomics and mass-spectrometry-based metabolomics. The bioinformatics tools for PoT deduction represent a core deliverable. A number of challenges for quality and standardization of cell systems, omics technologies and bioinformatics are being addressed. In parallel, concepts for annotation, validation and sharing of PoT information, as well as their link to adverse outcomes, are being developed. A reasonably comprehensive public database of PoT, the Human Toxome Knowledge-base, could become a point of reference for toxicological research and regulatory test strategies. regulatory toxicology, safety sciences, transcriptomics, metabolomics, alternative methods.
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U2 - 10.14573/altex.1502091
DO - 10.14573/altex.1502091
M3 - Article
C2 - 25742299
AN - SCOPUS:84927594869
SN - 1868-596X
VL - 32
SP - 112
EP - 124
JO - ALTEX : Alternativen zu Tierexperimenten
JF - ALTEX : Alternativen zu Tierexperimenten
IS - 2
ER -