Abstract
We have determined the genomic sequence of the human GSAA1 gene, a member of the family of acute-phase human serum amyloid A (SAA)-encoding genes. This sequence predicts a mature protein of 104 amino acids (aa), several of which differ from residues usually conserved in the sequence of SAA proteins isolated from serum. Despite coding differences, however, the four-exon structure of GSAA1 resembles that of other SAA genes in humans and mice. The N-terminal 25 aa of the mature GSAA1 protein are virtually identical to those of an 'SAA-like' autocrine collagenase inducer produced by rabbit synovial fibroblasts; the latter also differ from the corresponding aa found in SAA in serum. We propose that GSAA1 is the human gene coding for a protein closely related to the SAA, but which is adapted to this important autocrine cytokine function.
Original language | English (US) |
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Pages (from-to) | 509-515 |
Number of pages | 7 |
Journal | Gene |
Volume | 84 |
Issue number | 2 |
DOIs | |
State | Published - Dec 14 1989 |
Keywords
- Recombinant DNA
- acute phase stimuli
- cytokine
- exon
- inflammation
- intron
- rabbit
ASJC Scopus subject areas
- Genetics