The human pluripotent stem cell: Impact on medicine and society

Brian E. Edwards, John D. Gearhart, Edward E. Wallach

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Objective: To discuss the current state of the science surrounding human pluripotent stem cells and to show that the derivation of such cells from donated preimplantation human embryos should be eligible for federal funding provided that certain protections are met. Design: A literature search focusing on the scientific aspects of pluripotent stem-cell research and analyses of current and past legislation and federal panel recommendations. Conclusion(s): The current federal laws regulating the permissions necessary to obtain fetal tissue from elective pregnancy terminations are intended to insulate the decision to terminate a pregnancy from the potential positive influence of fetal tissue transplantation. A similar situation can be created for the derivation of cells from excess preimplantation human embryos produced by IVF programs. If, as in fetal tissue research, assurances can be made that the research will have no influence on the decision to dispose of the embryo, the derivation of pluripotent stem cells from embryo should proceed with federal funding.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalFertility and sterility
Issue number1
StatePublished - Jul 2000


  • Human pluripotent stem cell
  • Human pluripotent stem cell
  • fetal tissue research
  • fetal tissue transplantation research
  • human embryo research
  • human embryonic stem cell
  • medical ethics

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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