The human pineal gland in aging and Alzheimer's disease: patterns of cytoskeletal antigen immunoreactivity

C. A. Pardo; L. J. Martin; J. C. Troncoso; D. L. Price

doi:10.1007/BF00294615

The human pineal gland in aging and Alzheimer's disease: patterns of cytoskeletal antigen immunoreactivity

C. A. Pardo, L. J. Martin, J. C. Troncoso, D. L. Price

School of Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Patients with Alzheimer's disease (AD) and some aged controls may have diminished functions of the pineal gland. In this immunocytochemical study, we stained pineal glands from cases of AD and young and aged controls for cytoskeletal elements and amyloid. We found no evidence of neurofibrillary tangles (NFT) or the accumulation of neurofilaments, tau, A68, or β/A4 amyloid deposition in pinealocytes or associated structures in cases of AD or controls. In both AD and controls, we observed dense immunoreactivity for phosphorylated neurofilaments in marginal plexuses associated with processes of pinealocytes, boutons, and knob-like endings. The accumulation of phosphorylated neurofilaments in the processes of pinealocytes appears to be a normal morphological characteristic of the pineal gland and may not represent a pathological change.

Original language	English (US)
Pages (from-to)	535-540
Number of pages	6
Journal	Acta neuropathologica
Volume	80
Issue number	5
DOIs	https://doi.org/10.1007/BF00294615
State	Published - Sep 1990

Keywords

Neurofilament
Paraneurons
Pinealocytes
Tau

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1007/BF00294615

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abstract = "Patients with Alzheimer's disease (AD) and some aged controls may have diminished functions of the pineal gland. In this immunocytochemical study, we stained pineal glands from cases of AD and young and aged controls for cytoskeletal elements and amyloid. We found no evidence of neurofibrillary tangles (NFT) or the accumulation of neurofilaments, tau, A68, or β/A4 amyloid deposition in pinealocytes or associated structures in cases of AD or controls. In both AD and controls, we observed dense immunoreactivity for phosphorylated neurofilaments in marginal plexuses associated with processes of pinealocytes, boutons, and knob-like endings. The accumulation of phosphorylated neurofilaments in the processes of pinealocytes appears to be a normal morphological characteristic of the pineal gland and may not represent a pathological change.",

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T2 - patterns of cytoskeletal antigen immunoreactivity

AU - Pardo, C. A.

AU - Martin, L. J.

AU - Troncoso, J. C.

AU - Price, D. L.

PY - 1990/9

Y1 - 1990/9

N2 - Patients with Alzheimer's disease (AD) and some aged controls may have diminished functions of the pineal gland. In this immunocytochemical study, we stained pineal glands from cases of AD and young and aged controls for cytoskeletal elements and amyloid. We found no evidence of neurofibrillary tangles (NFT) or the accumulation of neurofilaments, tau, A68, or β/A4 amyloid deposition in pinealocytes or associated structures in cases of AD or controls. In both AD and controls, we observed dense immunoreactivity for phosphorylated neurofilaments in marginal plexuses associated with processes of pinealocytes, boutons, and knob-like endings. The accumulation of phosphorylated neurofilaments in the processes of pinealocytes appears to be a normal morphological characteristic of the pineal gland and may not represent a pathological change.

AB - Patients with Alzheimer's disease (AD) and some aged controls may have diminished functions of the pineal gland. In this immunocytochemical study, we stained pineal glands from cases of AD and young and aged controls for cytoskeletal elements and amyloid. We found no evidence of neurofibrillary tangles (NFT) or the accumulation of neurofilaments, tau, A68, or β/A4 amyloid deposition in pinealocytes or associated structures in cases of AD or controls. In both AD and controls, we observed dense immunoreactivity for phosphorylated neurofilaments in marginal plexuses associated with processes of pinealocytes, boutons, and knob-like endings. The accumulation of phosphorylated neurofilaments in the processes of pinealocytes appears to be a normal morphological characteristic of the pineal gland and may not represent a pathological change.

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KW - Tau

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The human pineal gland in aging and Alzheimer's disease: patterns of cytoskeletal antigen immunoreactivity

Abstract

Keywords

ASJC Scopus subject areas

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