TY - JOUR
T1 - The high burden of cholera in children
T2 - Comparison of incidence from endemic areas in Asia and Africa
AU - Deen, Jacqueline L.
AU - von Seidlein, Lorenz
AU - Sur, Dipika
AU - Agtini, Magdarina
AU - Lucas, Marcelino E.S.
AU - Lopez, Lena
AU - Kim, Deok Ryn
AU - Ali, Mohammad
AU - Clemens, John D.
PY - 2008/2
Y1 - 2008/2
N2 - Background: Cholera remains an important public health problem, Yet there are few reliable population-based estimates of laboratory-confirmed cholera incidence in endemic areas around the world. Methods: We established treatment facility-based cholera survelliance in three sites in Jakarta (Indonesia), Kolkata (India), and Beira (Mozambique), The annual incidence of cholera was estimated using the population census as the denominator and the age-specific number of cholera cases among the study cohort as the numerator. Findings: The lowest overall rate was found in Jakarta, where the estimated incidence was 0.5/1000 population/year. The incidence was three times higher in Kolkata (1.6/1000/year) and eight times higher in Baira (4.0/1000/year). In all study sites, the greatest burden was in children under 5 years of age. Conclusion: There are considerable differences in cholera incidence across these endemic areas but in all sites, children are the most affected. The study site in Africa had the highest cholera incidence consistant with a growing impression of the large cholera burden in Africa. Burden estimates are useful when considering where and among whom interventions such as vaccination would be most needed.
AB - Background: Cholera remains an important public health problem, Yet there are few reliable population-based estimates of laboratory-confirmed cholera incidence in endemic areas around the world. Methods: We established treatment facility-based cholera survelliance in three sites in Jakarta (Indonesia), Kolkata (India), and Beira (Mozambique), The annual incidence of cholera was estimated using the population census as the denominator and the age-specific number of cholera cases among the study cohort as the numerator. Findings: The lowest overall rate was found in Jakarta, where the estimated incidence was 0.5/1000 population/year. The incidence was three times higher in Kolkata (1.6/1000/year) and eight times higher in Baira (4.0/1000/year). In all study sites, the greatest burden was in children under 5 years of age. Conclusion: There are considerable differences in cholera incidence across these endemic areas but in all sites, children are the most affected. The study site in Africa had the highest cholera incidence consistant with a growing impression of the large cholera burden in Africa. Burden estimates are useful when considering where and among whom interventions such as vaccination would be most needed.
UR - http://www.scopus.com/inward/record.url?scp=48949118014&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48949118014&partnerID=8YFLogxK
U2 - 10.1371/journal.pntd.0000173
DO - 10.1371/journal.pntd.0000173
M3 - Article
C2 - 18299707
AN - SCOPUS:48949118014
SN - 1935-2727
VL - 2
JO - PLoS neglected tropical diseases
JF - PLoS neglected tropical diseases
IS - 2
M1 - e173
ER -