The Genome-Wide Molecular Landscape of HPV-Driven and HPV-Negative Head and Neck Squamous Cell Carcinoma

Farhoud Faraji; Adrian D. Schubert; Luciane T. Kagohara; Marietta Tan; Yanxun Xu; Munfarid Zaidi; Jean Philippe Fortin; Carole Fakhry; Evgeny Izumchenko; Daria A. Gaykalova; Elana J. Fertig

doi:10.1007/978-3-319-78762-6_11

The Genome-Wide Molecular Landscape of HPV-Driven and HPV-Negative Head and Neck Squamous Cell Carcinoma

Farhoud Faraji
, Adrian D. Schubert
, Luciane T. Kagohara
, Marietta Tan
, Yanxun Xu
, Munfarid Zaidi
, Jean Philippe Fortin
, Carole Fakhry
, Evgeny Izumchenko
, Daria A. Gaykalova
, Elana J. Fertig

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Recent advances in sequencing technology have enabled unprecedented genome-wide characterization of head and neck squamous cell carcinoma (HNSCC). Integrated analyses of publicly available multiplatform high-throughput data have uncovered the vast genomic, epigenetic, and transcriptional diversity of HNSCC. Recognition of human papillomavirus (HPV) involvement in HNSCC carcinogenesis has resulted in the categorization of two HNSCC subtypes (HPV-driven and HPV-negative) with distinct etiologies, molecular properties, clinical features, and prognostic outcomes. Differences in the molecular landscapes of HPV-driven and HPV-negative HNSCC occur genome-wide and encompass changes in genomic, epigenetic, and transcriptional landscapes. Even within each subtype, HNSCC tumors have substantial inter-tumor and intra-tumor molecular heterogeneity. Improving the understanding of the underlying biological function of these complex molecular landscapes through emerging cross-platform genomic analyses is essential to developing more effective diagnostic and therapeutic strategies for HNSCC.

Original language	English (US)
Title of host publication	Current Cancer Research
Publisher	Springer Nature
Pages	293-325
Number of pages	33
DOIs	https://doi.org/10.1007/978-3-319-78762-6_11
State	Published - 2018

Publication series

Name	Current Cancer Research
ISSN (Print)	2199-2584
ISSN (Electronic)	2199-2592

Keywords

Alternative splicing
Epigenetics
Gene fusion
Genomics
Head and neck squamous cell carcinoma
Heterogeneity
Human papillomavirus
Immunotherapy
Mutation
Transcriptomics

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/978-3-319-78762-6_11

Cite this

Faraji, F., Schubert, A. D., Kagohara, L. T., Tan, M., Xu, Y., Zaidi, M., Fortin, J. P., Fakhry, C., Izumchenko, E., Gaykalova, D. A., & Fertig, E. J. (2018). The Genome-Wide Molecular Landscape of HPV-Driven and HPV-Negative Head and Neck Squamous Cell Carcinoma. In Current Cancer Research (pp. 293-325). (Current Cancer Research). Springer Nature. https://doi.org/10.1007/978-3-319-78762-6_11

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title = "The Genome-Wide Molecular Landscape of HPV-Driven and HPV-Negative Head and Neck Squamous Cell Carcinoma",

abstract = "Recent advances in sequencing technology have enabled unprecedented genome-wide characterization of head and neck squamous cell carcinoma (HNSCC). Integrated analyses of publicly available multiplatform high-throughput data have uncovered the vast genomic, epigenetic, and transcriptional diversity of HNSCC. Recognition of human papillomavirus (HPV) involvement in HNSCC carcinogenesis has resulted in the categorization of two HNSCC subtypes (HPV-driven and HPV-negative) with distinct etiologies, molecular properties, clinical features, and prognostic outcomes. Differences in the molecular landscapes of HPV-driven and HPV-negative HNSCC occur genome-wide and encompass changes in genomic, epigenetic, and transcriptional landscapes. Even within each subtype, HNSCC tumors have substantial inter-tumor and intra-tumor molecular heterogeneity. Improving the understanding of the underlying biological function of these complex molecular landscapes through emerging cross-platform genomic analyses is essential to developing more effective diagnostic and therapeutic strategies for HNSCC.",

keywords = "Alternative splicing, Epigenetics, Gene fusion, Genomics, Head and neck squamous cell carcinoma, Heterogeneity, Human papillomavirus, Immunotherapy, Mutation, Transcriptomics",

author = "Farhoud Faraji and Schubert, \{Adrian D.\} and Kagohara, \{Luciane T.\} and Marietta Tan and Yanxun Xu and Munfarid Zaidi and Fortin, \{Jean Philippe\} and Carole Fakhry and Evgeny Izumchenko and Gaykalova, \{Daria A.\} and Fertig, \{Elana J.\}",

note = "Publisher Copyright: {\textcopyright} 2018, Springer International Publishing AG, part of Springer Nature.",

year = "2018",

doi = "10.1007/978-3-319-78762-6\_11",

language = "English (US)",

series = "Current Cancer Research",

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AU - Tan, Marietta

AU - Xu, Yanxun

AU - Zaidi, Munfarid

AU - Fortin, Jean Philippe

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AU - Izumchenko, Evgeny

AU - Gaykalova, Daria A.

AU - Fertig, Elana J.

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AB - Recent advances in sequencing technology have enabled unprecedented genome-wide characterization of head and neck squamous cell carcinoma (HNSCC). Integrated analyses of publicly available multiplatform high-throughput data have uncovered the vast genomic, epigenetic, and transcriptional diversity of HNSCC. Recognition of human papillomavirus (HPV) involvement in HNSCC carcinogenesis has resulted in the categorization of two HNSCC subtypes (HPV-driven and HPV-negative) with distinct etiologies, molecular properties, clinical features, and prognostic outcomes. Differences in the molecular landscapes of HPV-driven and HPV-negative HNSCC occur genome-wide and encompass changes in genomic, epigenetic, and transcriptional landscapes. Even within each subtype, HNSCC tumors have substantial inter-tumor and intra-tumor molecular heterogeneity. Improving the understanding of the underlying biological function of these complex molecular landscapes through emerging cross-platform genomic analyses is essential to developing more effective diagnostic and therapeutic strategies for HNSCC.

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KW - Head and neck squamous cell carcinoma

KW - Heterogeneity

KW - Human papillomavirus

KW - Immunotherapy

KW - Mutation

KW - Transcriptomics

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PB - Springer Nature

ER -

The Genome-Wide Molecular Landscape of HPV-Driven and HPV-Negative Head and Neck Squamous Cell Carcinoma

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ASJC Scopus subject areas

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