The genetics of thyroiditis as a prototype of human autoimmune disease

N. R. Rose, C. L. Burek

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


The predisposition to autoimmune disease has been termed an autoimmune diathesis. The genetic basis for this predisposition has been analyzed, using three different models: juvenile thyroiditis in humans, spontaneous thyroiditis in chickens, and experimental thyroiditis in mice. At least three different categories of genetic factors contribute to the development of autoimmunity. They include an increased immune response due to immunoregulatory genes associated with the major histocompatibility complex, the balance of thymus-derived lymphocyte population with helper/inducer vs suppressor properties, and intrinsic metabolic abnormalities of the target thyroid cells.

Original languageEnglish (US)
Pages (from-to)261-271
Number of pages11
JournalAnnals of allergy
Issue number4
StatePublished - 1985

ASJC Scopus subject areas

  • Immunology and Allergy


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