The genetics of Parkinson's disease.

Kah Leong Lim; Valina L. Dawson; Ted M. Dawson

doi:10.1007/s11910-002-0071-9

The genetics of Parkinson's disease.

Kah Leong Lim, Valina L. Dawson, Ted M. Dawson

School of Medicine

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

The recent identification of several genes and gene loci linked to familial forms of Parkinson's disease (PD) has contributed significantly to our understanding of the genetic contribution in PD. Although the etiology of sporadic PD remains unknown, it is currently assumed that genetic susceptibilities may be involved. The advent of genome-wide scanning techniques has now made it possible to conduct complete genome screens for linkage in PD in multigenerational parkinsonian kindreds. Such studies undoubtedly will be instrumental in establishing the susceptibility genes involved in idiopathic PD. This article reviews the recent advances in the genetics of PD.

Original language	English (US)
Pages (from-to)	439-446
Number of pages	8
Journal	Current neurology and neuroscience reports
Volume	2
Issue number	5
DOIs	https://doi.org/10.1007/s11910-002-0071-9
State	Published - Sep 2002

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

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title = "The genetics of Parkinson's disease.",

abstract = "The recent identification of several genes and gene loci linked to familial forms of Parkinson's disease (PD) has contributed significantly to our understanding of the genetic contribution in PD. Although the etiology of sporadic PD remains unknown, it is currently assumed that genetic susceptibilities may be involved. The advent of genome-wide scanning techniques has now made it possible to conduct complete genome screens for linkage in PD in multigenerational parkinsonian kindreds. Such studies undoubtedly will be instrumental in establishing the susceptibility genes involved in idiopathic PD. This article reviews the recent advances in the genetics of PD.",

author = "Lim, {Kah Leong} and Dawson, {Valina L.} and Dawson, {Ted M.}",

note = "Funding Information: This work was supported by the Parkinson{\textquoteright}s Disease Society, UK, the Progressive Supranuclear Palsy (Europe) Association, the Brain Research Trust and the Reta Lila Weston Trust. ",

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AU - Lim, Kah Leong

AU - Dawson, Valina L.

AU - Dawson, Ted M.

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N2 - The recent identification of several genes and gene loci linked to familial forms of Parkinson's disease (PD) has contributed significantly to our understanding of the genetic contribution in PD. Although the etiology of sporadic PD remains unknown, it is currently assumed that genetic susceptibilities may be involved. The advent of genome-wide scanning techniques has now made it possible to conduct complete genome screens for linkage in PD in multigenerational parkinsonian kindreds. Such studies undoubtedly will be instrumental in establishing the susceptibility genes involved in idiopathic PD. This article reviews the recent advances in the genetics of PD.

AB - The recent identification of several genes and gene loci linked to familial forms of Parkinson's disease (PD) has contributed significantly to our understanding of the genetic contribution in PD. Although the etiology of sporadic PD remains unknown, it is currently assumed that genetic susceptibilities may be involved. The advent of genome-wide scanning techniques has now made it possible to conduct complete genome screens for linkage in PD in multigenerational parkinsonian kindreds. Such studies undoubtedly will be instrumental in establishing the susceptibility genes involved in idiopathic PD. This article reviews the recent advances in the genetics of PD.

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The genetics of Parkinson's disease.

Abstract

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