The future of pediatric cancer and complex diseases: Aren't they all?

Stephen Chanock, Meredith Yeager

Research output: Contribution to journalReview articlepeer-review


Over the past decade, the investigation of human genetics and disease has pursued both common and uncommon germ-line variation and shown that both can be associated with altered risk for cancer and its outcomes. This line of investigation has not only begun to generate markers for disease but also insights into the biological pathways that are altered in cancer. Already, there is emerging evidence that germ-line genetic variation can alter susceptibility to different types of cancers, including pediatric cancers. It is evident that common genetic variation has emerged as a key component of a comprehensive understanding of pediatric cancer and its outcome. Future studies should unravel the complex interaction between genes and the environment.

Original languageEnglish (US)
Pages (from-to)719-722
Number of pages4
JournalPediatric Blood and Cancer
Issue number7
StatePublished - Jun 15 2007
Externally publishedYes


  • Complex diseases
  • Pediatric cancer
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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