The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria

Valentin K. Gribkoff, Elizabeth A. Jonas, J Marie Hardwick

Research output: Book/ReportBook


This book presents advances in the field of neuronal mitochondria - functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases. Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death. Offers insights on the development of strategies for targeted therapeutic approaches and potential personalized treatments. Includes examples of mitochondrial drugs, development, and mitochondria-targeted approaches for more efficient treatment methods and further developments in the field. Covers the model systems and approaches needed for the development of new drugs for the central nervous system to provide potential modern therapeutics for neurodegenerative disorders.

Original languageEnglish (US)
Number of pages425
ISBN (Electronic)9781119017127
ISBN (Print)9781118709238
StatePublished - Sep 25 2015

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)
  • Chemistry(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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