The expression of HLA antigens by cells in the human cornea

Patrick A. Treseler, Gary N. Foulks, Fred Sanfilippo

Research output: Contribution to journalArticlepeer-review

103 Scopus citations


Although antigens of the human major histocompatibility complex, HLA, appear to be involved in the rejection of corneal allografts, the expression of these antigens by cells of the human cornea remains controversial. Using sensitive immunoperoxidase techniques, we readily demonstrated class I HLA antigens on corneal epithelial, stromal, and endothelial cells, regardless of donor age. Moreover, the expression of class I antigens by epithelium increased markedly from the central to the peripheral cornea. Finally, class II HLA antigens were found on cells scattered throughout both central and peripheral epithelium as well as the stroma. A cornea obtained from a donor of known HLA type expressed all expected and no unexpected polymorphic HLA determinants in the cornea, in a pattern similar to that seen for monomorphic HLA determinants.

Original languageEnglish (US)
Pages (from-to)763-772
Number of pages10
JournalAmerican Journal of Ophthalmology
Issue number6
StatePublished - Dec 15 1984
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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