The etiology of adolescent idiopathic scoliosis.

Uri Michael Ahn, Nicholas U. Ahn, Leelakrishna Nallamshetty, Jacob M. Buchowski, Peter S. Rose, Nancy H. Miller, John P. Kostuik, Paul D. Sponseller

Research output: Contribution to journalReview articlepeer-review

83 Scopus citations


The etiology of adolescent idiopathic scoliosis (AIS), the most common form of scoliosis, is unclear. Researchers with divergent perspectives have tried to better define this etiology. Genetics, growth hormone secretion, connective tissue structure, muscle structure, vestibular dysfunction, melatonin secretion, and platelet microstructure are major areas of focus. In this article, we review the literature in these areas and present the consensus on proposed hypotheses. Studies that simplify the etiology to a single factor have been inconclusive or unsuccessful. Most likely, the etiology is multifactorial, and reported associations are links in pathogenesis rather than etiologic factors. Research is needed to better define the role of all factors in AIS development.

Original languageEnglish (US)
Pages (from-to)387-395
Number of pages9
JournalAmerican journal of orthopedics (Belle Mead, N.J.)
Issue number7
StatePublished - Jul 2002
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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