The endoscopic appearance of the duodenum in Whipple's disease

N. A. Volpicelli, W. R. Salyer, F. D. Milligan, T. M. Bayless, J. H. Yardley

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Duodenoscopic examination of a patient with Whipple's disease revealed that the duodenal mucosa appeared to be partially covered with a yellow white material. On closer inspection, however, this was found to consist of enlarged villi interspersed with normal looking mucosa. Histologically these enlarged white villi were shown to contain a heavy accumulation of lipid and typical PAS positive macrophages. The duodenal mucosa was endoscopically normal and histologically showed only a few PAS positive macrophages one year after instituting antibiotic therapy.

Original languageEnglish (US)
Pages (from-to)19-23
Number of pages5
JournalJohns Hopkins Medical Journal
Issue number1
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Medicine(all)


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