The emerging significance of O-GlcNAc in cellular regulation

Natasha E. Zachara, Gerald W. Hart

Research output: Contribution to journalArticlepeer-review

248 Scopus citations


Recently, perturbations in the regulation of O-GlcNAc were implicated in the etiology of type II diabetes, cancer, and neurodegenerative diseases. O-GlcNAc, the modification of Ser and Thr residues of nuclear and cytoplasmic proteins with O-linked β-N-acetylglucosamine, is one of a growing number of posttranslational modifications of proteins thought to modulate the function/activity of proteins in cells. This paper reviews the current understanding of the importance of the unique carbohydrate modification O-GlcNAc, in regulating functions within the cell.

Original languageEnglish (US)
Pages (from-to)431-438
Number of pages8
JournalChemical Reviews
Issue number2
StatePublished - Feb 2002

ASJC Scopus subject areas

  • Chemistry(all)


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