The emerging significance of O-GlcNAc in cellular regulation

Natasha E. Zachara; Gerald W. Hart

doi:10.1021/cr000406u

The emerging significance of O-GlcNAc in cellular regulation

Natasha E. Zachara, Gerald W. Hart

School of Medicine

Research output: Contribution to journal › Article › peer-review

248 Scopus citations

Abstract

Recently, perturbations in the regulation of O-GlcNAc were implicated in the etiology of type II diabetes, cancer, and neurodegenerative diseases. O-GlcNAc, the modification of Ser and Thr residues of nuclear and cytoplasmic proteins with O-linked β-N-acetylglucosamine, is one of a growing number of posttranslational modifications of proteins thought to modulate the function/activity of proteins in cells. This paper reviews the current understanding of the importance of the unique carbohydrate modification O-GlcNAc, in regulating functions within the cell.

Original language	English (US)
Pages (from-to)	431-438
Number of pages	8
Journal	Chemical Reviews
Volume	102
Issue number	2
DOIs	https://doi.org/10.1021/cr000406u
State	Published - Feb 2002

ASJC Scopus subject areas

Chemistry(all)

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10.1021/cr000406u

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abstract = "Recently, perturbations in the regulation of O-GlcNAc were implicated in the etiology of type II diabetes, cancer, and neurodegenerative diseases. O-GlcNAc, the modification of Ser and Thr residues of nuclear and cytoplasmic proteins with O-linked β-N-acetylglucosamine, is one of a growing number of posttranslational modifications of proteins thought to modulate the function/activity of proteins in cells. This paper reviews the current understanding of the importance of the unique carbohydrate modification O-GlcNAc, in regulating functions within the cell.",

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AB - Recently, perturbations in the regulation of O-GlcNAc were implicated in the etiology of type II diabetes, cancer, and neurodegenerative diseases. O-GlcNAc, the modification of Ser and Thr residues of nuclear and cytoplasmic proteins with O-linked β-N-acetylglucosamine, is one of a growing number of posttranslational modifications of proteins thought to modulate the function/activity of proteins in cells. This paper reviews the current understanding of the importance of the unique carbohydrate modification O-GlcNAc, in regulating functions within the cell.

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The emerging significance of O-GlcNAc in cellular regulation

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