The emergence of systematic review in toxicology

Martin L. Stephens, Kellyn Betts, Nancy B. Beck, Vincent Cogliano, Kay Dickersin, Suzanne Fitzpatrick, James Freeman, George Gray, Thomas Hartung, Jennifer McPartland, Andrew A. Rooney, Roberta W. Scherer, Didier Verloo, Sebastian Hoffmann

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


The Evidence-based Toxicology Collaboration hosted a workshop on "The Emergence of Systematic Review and Related Evidence-based Approaches in Toxicology," on November 21, 2014 in Baltimore, Maryland. The workshop featured speakers from agencies and organizations applying systematic review approaches to questions in toxicology, speakers with experience in conducting systematic reviews in medicine and healthcare, and stakeholders in industry, government, academia, and non-governmental organizations. Based on the workshop presentations and discussion, here we address the state of systematic review methods in toxicology, historical antecedents in both medicine and toxicology, challenges to the translation of systematic review from medicine to toxicology, and thoughts on the way forward. We conclude with a recommendation that as various agencies and organizations adapt systematic review methods, they continue to work together to ensure that there is a harmonized process for how the basic elements of systematic review methods are applied in toxicology.

Original languageEnglish (US)
Article numberkfw059
Pages (from-to)10-16
Number of pages7
JournalToxicological Sciences
Issue number1
StatePublished - Jul 1 2016


  • Data integration
  • Risk of bias
  • Systematic review

ASJC Scopus subject areas

  • Toxicology


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