The emergence of extensively drug-resistant tuberculosis: A global health crisis requiring new interventions: Part I: The origins and nature of the problem

Jerrold J. Ellner

doi:10.1111/j.1752-8062.2008.00060.x

The emergence of extensively drug-resistant tuberculosis: A global health crisis requiring new interventions: Part I: The origins and nature of the problem

Jerrold J. Ellner

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Surveillance studies and outbreak investigations indicate that an extensively drug-resistant (XDR) form of tuberculosis (TB) is increasing in prevalence worldwide. In outbreak settings among HIV-infected, there is a high-case fatality rate. Better outcomes occur in HIV-uninfected, particularly if drug susceptibility test (DST) results are available rapidly to allow tailoring of drug therapy. This review will be presented in two segments. The first characterizes the problem posed by XDR-TB, addressing the epidemiology and evolution of XDR-TB and treatment outcomes. The second reviews technologic advances that may contribute to the solution, new diagnostics, and advances in understanding drug resistance and in the development of new drugs.

Original language	English (US)
Pages (from-to)	249-254
Number of pages	6
Journal	Clinical and Translational Science
Volume	1
Issue number	3
DOIs	https://doi.org/10.1111/j.1752-8062.2008.00060.x
State	Published - Dec 2008
Externally published	Yes

Keywords

Drug resistant tuberculosis
Extensively drug resistant tuberculosis
Multidrug resistant tuberculosis
Tuberculosis

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology
General Neuroscience
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1111/j.1752-8062.2008.00060.x

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The emergence of extensively drug-resistant tuberculosis: A global health crisis requiring new interventions: Part I: The origins and nature of the problem

Abstract

Keywords

ASJC Scopus subject areas

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