The effects of placental malaria on mother-to-child HIV transmission in Rakai, Uganda

Heena Brahmbhatt; Godfrey Kigozi; Fred Wabwire-Mangen; David Serwadda; Nelson Sewankambo; Tom Lutalo; Maria J. Wawer; Carlos Abramowsky; David Sullivan; Ronald Gray

doi:10.1097/00002030-200311210-00020

The effects of placental malaria on mother-to-child HIV transmission in Rakai, Uganda

Heena Brahmbhatt, Godfrey Kigozi, Fred Wabwire-Mangen, David Serwadda, Nelson Sewankambo, Tom Lutalo, Maria J. Wawer, Carlos Abramowsky, David Sullivan, Ronald Gray

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

We examined the association of placental malaria and mother-to-child transmission (MTCT) of HIV in a prospective community-randomized trial in Rakai District, Uganda. In the 746 HIV-positive mother-infant pairs, the MTCT rate was 20.4%. Placental malaria was more common in HIV-positive than HIV-negative women. After multivariate adjustment for HIV viral load, the risk of MTCT associated with placental malaria was 2.89 and with HIV viral load the risk was 2.85. Interventions to prevent malaria during pregnancy could potentially reduce MTCT.

Original language	English (US)
Pages (from-to)	2539-2541
Number of pages	3
Journal	AIDS
Volume	17
Issue number	17
DOIs	https://doi.org/10.1097/00002030-200311210-00020
State	Published - Nov 21 2003

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1097/00002030-200311210-00020

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abstract = "We examined the association of placental malaria and mother-to-child transmission (MTCT) of HIV in a prospective community-randomized trial in Rakai District, Uganda. In the 746 HIV-positive mother-infant pairs, the MTCT rate was 20.4%. Placental malaria was more common in HIV-positive than HIV-negative women. After multivariate adjustment for HIV viral load, the risk of MTCT associated with placental malaria was 2.89 and with HIV viral load the risk was 2.85. Interventions to prevent malaria during pregnancy could potentially reduce MTCT.",

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AU - Wabwire-Mangen, Fred

AU - Serwadda, David

AU - Sewankambo, Nelson

AU - Lutalo, Tom

AU - Wawer, Maria J.

AU - Abramowsky, Carlos

AU - Sullivan, David

AU - Gray, Ronald

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AB - We examined the association of placental malaria and mother-to-child transmission (MTCT) of HIV in a prospective community-randomized trial in Rakai District, Uganda. In the 746 HIV-positive mother-infant pairs, the MTCT rate was 20.4%. Placental malaria was more common in HIV-positive than HIV-negative women. After multivariate adjustment for HIV viral load, the risk of MTCT associated with placental malaria was 2.89 and with HIV viral load the risk was 2.85. Interventions to prevent malaria during pregnancy could potentially reduce MTCT.

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The effects of placental malaria on mother-to-child HIV transmission in Rakai, Uganda

Abstract

ASJC Scopus subject areas

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