The effects of inorganic lead on the neuromuscular junction

Ellen K. Silbergeld; J. T. Fales; A. M. Goldberg

doi:10.1016/0028-3908(74)90034-3

The effects of inorganic lead on the neuromuscular junction

Ellen K. Silbergeld, J. T. Fales, A. M. Goldberg

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The effects of inorganic lead on neuromuscular function were examined using the rat and mouse phrenic nerve-hemidiaphragm preparations. In vitro lead was found to decrease the force of contraction and to increase the latency between nerve stimulation and contraction. These effects were not seen when the muscle was stimulated directly. Responses of lead-treated preparations to acetylcholine and acetyl-β-methylcholine were unchanged. In addition, neuromuscular function was impaired in mice chronically exposed to lead. The results support the hypothesis of a prejunctional site of action of inorganic lead.

Original language	English (US)
Pages (from-to)	795-801
Number of pages	7
Journal	Neuropharmacology
Volume	13
Issue number	9
DOIs	https://doi.org/10.1016/0028-3908(74)90034-3
State	Published - Sep 1974
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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title = "The effects of inorganic lead on the neuromuscular junction",

abstract = "The effects of inorganic lead on neuromuscular function were examined using the rat and mouse phrenic nerve-hemidiaphragm preparations. In vitro lead was found to decrease the force of contraction and to increase the latency between nerve stimulation and contraction. These effects were not seen when the muscle was stimulated directly. Responses of lead-treated preparations to acetylcholine and acetyl-β-methylcholine were unchanged. In addition, neuromuscular function was impaired in mice chronically exposed to lead. The results support the hypothesis of a prejunctional site of action of inorganic lead.",

author = "Silbergeld, {Ellen K.} and Fales, {J. T.} and Goldberg, {A. M.}",

note = "Funding Information: Acknowlrdyernents~The work was supported in part by grants from NIEHS 00034 and SILBERGELDi s recipient of a Joseph P. Kennedy Fellowship in the Neurosciences,",

year = "1974",

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AU - Silbergeld, Ellen K.

AU - Fales, J. T.

AU - Goldberg, A. M.

N1 - Funding Information: Acknowlrdyernents~The work was supported in part by grants from NIEHS 00034 and SILBERGELDi s recipient of a Joseph P. Kennedy Fellowship in the Neurosciences,

PY - 1974/9

Y1 - 1974/9

N2 - The effects of inorganic lead on neuromuscular function were examined using the rat and mouse phrenic nerve-hemidiaphragm preparations. In vitro lead was found to decrease the force of contraction and to increase the latency between nerve stimulation and contraction. These effects were not seen when the muscle was stimulated directly. Responses of lead-treated preparations to acetylcholine and acetyl-β-methylcholine were unchanged. In addition, neuromuscular function was impaired in mice chronically exposed to lead. The results support the hypothesis of a prejunctional site of action of inorganic lead.

AB - The effects of inorganic lead on neuromuscular function were examined using the rat and mouse phrenic nerve-hemidiaphragm preparations. In vitro lead was found to decrease the force of contraction and to increase the latency between nerve stimulation and contraction. These effects were not seen when the muscle was stimulated directly. Responses of lead-treated preparations to acetylcholine and acetyl-β-methylcholine were unchanged. In addition, neuromuscular function was impaired in mice chronically exposed to lead. The results support the hypothesis of a prejunctional site of action of inorganic lead.

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The effects of inorganic lead on the neuromuscular junction

Abstract

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