The effects of illicit drug use and HIV infection on sex hormone levels in women

Joseph Cofrancesco, Nina Shah, Khalil Ghanem, Adrian Dobs, Robert Klein, Kenneth Mayer, Paula Schuman, David Vlahov, Anne Rompalo

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Drug use and HIV infection may affect sex hormone levels in women. One hundred and ninety-six women with and without a history of illicit drug use (50 HIV-negative and 148 HIV-infected), with regular menses, who never used antiretrovirals, were evaluated. Luteinizing hormone levels were significantly higher in women with a CD4 cell count p p = 0.03) and higher levels of prolactin ( p = 0.002); mean estradiol levels were 43% lower in women who used intravenous drugs (p < 0.001). Alcohol and crack cocaine use was not associated with sex hormone levels. Age, race, body mass index and degree of HIV immunosuppression were also associated with differences in sex hormone levels.

Original languageEnglish (US)
Pages (from-to)244-251
Number of pages8
JournalGynecological Endocrinology
Issue number5
StatePublished - May 1 2006


  • AIDS
  • HIV
  • Injection drug use
  • Sex hormones
  • Testosterone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Obstetrics and Gynecology


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