The effects of environmental factors associated with childhood urbanicity on brain structure and cognition

Xiao Zhang; Hao Yan; Hao Yu; Yuyanan Zhang; Hao Yang Tan; Dai Zhang; Weihua Yue

doi:10.1186/s12888-023-05066-3

The effects of environmental factors associated with childhood urbanicity on brain structure and cognition

Xiao Zhang, Hao Yan, Hao Yu, Yuyanan Zhang, Hao Yang Tan, Dai Zhang, Weihua Yue

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Urbanization is a trend lasting for more than one century worldwide. Four hundred ninety male and female adult Chinese Han participants with different urban and rural childhoods were included in this study. Early-life urban environment was found benefit for total grey matter volume (GMV), dorsolateral prefrontal cortex (DLPFC) GMV, temporal pole (TP) GMV and cognition function, and negatively correlated with medial prefrontal cortex (MPFC) GMV. Regression analysis showed that maternal education was a protective factor for total and DLPFC GMVs, while having siblings was better for MPFC GMV. Total, DLPFC and TP GMVs acts mediation effects between childhood urbanicity and different cognitive domains. These findings may suggest some pros and cons on brain structure associated with childhood urbanicity and related environmental factors.

Original language	English (US)
Article number	598
Journal	BMC psychiatry
Volume	23
Issue number	1
DOIs	https://doi.org/10.1186/s12888-023-05066-3
State	Published - Dec 2023

Keywords

Childhood environment
Cognition
Grey matter volume
Having siblings
Maternal education
Urbanicity

ASJC Scopus subject areas

Psychiatry and Mental health

Access to Document

10.1186/s12888-023-05066-3

Cite this

@article{b8ebfb4cf938453c804f7ba9fe7db79d,

title = "The effects of environmental factors associated with childhood urbanicity on brain structure and cognition",

abstract = "Urbanization is a trend lasting for more than one century worldwide. Four hundred ninety male and female adult Chinese Han participants with different urban and rural childhoods were included in this study. Early-life urban environment was found benefit for total grey matter volume (GMV), dorsolateral prefrontal cortex (DLPFC) GMV, temporal pole (TP) GMV and cognition function, and negatively correlated with medial prefrontal cortex (MPFC) GMV. Regression analysis showed that maternal education was a protective factor for total and DLPFC GMVs, while having siblings was better for MPFC GMV. Total, DLPFC and TP GMVs acts mediation effects between childhood urbanicity and different cognitive domains. These findings may suggest some pros and cons on brain structure associated with childhood urbanicity and related environmental factors.",

keywords = "Childhood environment, Cognition, Grey matter volume, Having siblings, Maternal education, Urbanicity",

author = "Xiao Zhang and Hao Yan and Hao Yu and Yuyanan Zhang and Tan, {Hao Yang} and Dai Zhang and Weihua Yue",

note = "Publisher Copyright: {\textcopyright} 2023, BioMed Central Ltd., part of Springer Nature.",

year = "2023",

month = dec,

doi = "10.1186/s12888-023-05066-3",

language = "English (US)",

volume = "23",

journal = "BMC psychiatry",

issn = "1471-244X",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - The effects of environmental factors associated with childhood urbanicity on brain structure and cognition

AU - Zhang, Xiao

AU - Yan, Hao

AU - Yu, Hao

AU - Zhang, Yuyanan

AU - Tan, Hao Yang

AU - Zhang, Dai

AU - Yue, Weihua

PY - 2023/12

Y1 - 2023/12

N2 - Urbanization is a trend lasting for more than one century worldwide. Four hundred ninety male and female adult Chinese Han participants with different urban and rural childhoods were included in this study. Early-life urban environment was found benefit for total grey matter volume (GMV), dorsolateral prefrontal cortex (DLPFC) GMV, temporal pole (TP) GMV and cognition function, and negatively correlated with medial prefrontal cortex (MPFC) GMV. Regression analysis showed that maternal education was a protective factor for total and DLPFC GMVs, while having siblings was better for MPFC GMV. Total, DLPFC and TP GMVs acts mediation effects between childhood urbanicity and different cognitive domains. These findings may suggest some pros and cons on brain structure associated with childhood urbanicity and related environmental factors.

AB - Urbanization is a trend lasting for more than one century worldwide. Four hundred ninety male and female adult Chinese Han participants with different urban and rural childhoods were included in this study. Early-life urban environment was found benefit for total grey matter volume (GMV), dorsolateral prefrontal cortex (DLPFC) GMV, temporal pole (TP) GMV and cognition function, and negatively correlated with medial prefrontal cortex (MPFC) GMV. Regression analysis showed that maternal education was a protective factor for total and DLPFC GMVs, while having siblings was better for MPFC GMV. Total, DLPFC and TP GMVs acts mediation effects between childhood urbanicity and different cognitive domains. These findings may suggest some pros and cons on brain structure associated with childhood urbanicity and related environmental factors.

KW - Childhood environment

KW - Cognition

KW - Grey matter volume

KW - Having siblings

KW - Maternal education

KW - Urbanicity

UR - http://www.scopus.com/inward/record.url?scp=85168271281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85168271281&partnerID=8YFLogxK

U2 - 10.1186/s12888-023-05066-3

DO - 10.1186/s12888-023-05066-3

M3 - Article

C2 - 37592210

AN - SCOPUS:85168271281

SN - 1471-244X

VL - 23

JO - BMC psychiatry

JF - BMC psychiatry

IS - 1

M1 - 598

ER -

The effects of environmental factors associated with childhood urbanicity on brain structure and cognition

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this