The effects of clozapine on neurocognition: An overview

T. E. Goldberg, D. R. Weinberger

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


Clozapine has proved effective in alleviating a wide range of psychiatric symptoms in schizophrenia. Its effects on cognitive function in schizophrenia are more variable. Clozapine appears to have a salutary effect on some aspects of attention, response speed, and fluency, whereas it appears to have a mild but adverse effect on visual memory and some executive functions. This profile may be related to the affinity of clozapine for dopaminergic type I and muscarinic receptors and relative lack of affinity for dopaminergic type II receptors.

Original languageEnglish (US)
Pages (from-to)88-90
Number of pages3
JournalJournal of Clinical Psychiatry
Issue number9 SUPPL. B
StatePublished - Nov 16 1994
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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