TY - JOUR
T1 - The Effect of Xanthine Oxidase Inhibition Upon Ejection Fraction in Heart Failure Patients
T2 - La Plata Study
AU - Cingolani, Horacio E.
AU - Plastino, Juan A.
AU - Escudero, Eduardo M.
AU - Mangal, Brian
AU - Brown, Joanne
AU - Pérez, Néstor G.
PY - 2006/9/1
Y1 - 2006/9/1
N2 - Background: Reactive oxygen species (ROS) have been linked to hypertrophy, remodeling and abnormal excitation-contraction coupling. Previous data demonstrated that an increase in oxidative stress is associated to the pathogenesis of congestive heart failure (CHF). We examined whether inhibition of the superoxide anion (·O 2 -)-generating enzyme xanthine oxidase (XO) with oxypurinol may improve cardiac function in patients with CHF. Methods and Results: A randomized, placebo-controlled, double-blind study on 60 patients (30/group) with New York Heart Association class II-III CHF, comparing 600-mg/day oxypurinol during 1 month with placebo, added to standard therapy. Effects on left ventricular ejection fraction (LVEF), serum uric acid (SUA) level, and 6-minute walking test were analyzed. SUA decreased by 16.0 ± 2.8 mg/L from baseline to Week 4 in the oxypurinol group relative to placebo (P < .01, n = 30 per group). LVEF showed an increase of 4.7 ± 2.6% from baseline to Week 4 in the oxypurinol group relative to placebo that did not reach statistical significance (P < .08). When patients with LVEF >40% at baseline were excluded, a statistically significant increase of 6.8 ± 2.8% from baseline to Week 4 was seen in the oxypurinol group relative to placebo (P < .02, n = 26 placebo, n = 21 oxypurinol). No treatment-related adverse effects or increase in walking capacity were detected. Conclusion: Inhibition of XO by oxypurinol in patients with CHF decreases SUA and improves LVEF in patients with LVEF ≤40% after 1 month of treatment.
AB - Background: Reactive oxygen species (ROS) have been linked to hypertrophy, remodeling and abnormal excitation-contraction coupling. Previous data demonstrated that an increase in oxidative stress is associated to the pathogenesis of congestive heart failure (CHF). We examined whether inhibition of the superoxide anion (·O 2 -)-generating enzyme xanthine oxidase (XO) with oxypurinol may improve cardiac function in patients with CHF. Methods and Results: A randomized, placebo-controlled, double-blind study on 60 patients (30/group) with New York Heart Association class II-III CHF, comparing 600-mg/day oxypurinol during 1 month with placebo, added to standard therapy. Effects on left ventricular ejection fraction (LVEF), serum uric acid (SUA) level, and 6-minute walking test were analyzed. SUA decreased by 16.0 ± 2.8 mg/L from baseline to Week 4 in the oxypurinol group relative to placebo (P < .01, n = 30 per group). LVEF showed an increase of 4.7 ± 2.6% from baseline to Week 4 in the oxypurinol group relative to placebo that did not reach statistical significance (P < .08). When patients with LVEF >40% at baseline were excluded, a statistically significant increase of 6.8 ± 2.8% from baseline to Week 4 was seen in the oxypurinol group relative to placebo (P < .02, n = 26 placebo, n = 21 oxypurinol). No treatment-related adverse effects or increase in walking capacity were detected. Conclusion: Inhibition of XO by oxypurinol in patients with CHF decreases SUA and improves LVEF in patients with LVEF ≤40% after 1 month of treatment.
KW - Heart failure
KW - Left ventricular ejection fraction
KW - Trials
KW - Uric acid
KW - Xanthine oxidase inhibition
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U2 - 10.1016/j.cardfail.2006.05.005
DO - 10.1016/j.cardfail.2006.05.005
M3 - Article
C2 - 16952781
AN - SCOPUS:33748116331
SN - 1071-9164
VL - 12
SP - 491
EP - 498
JO - Journal of cardiac failure
JF - Journal of cardiac failure
IS - 7
ER -