The effect of the cystic fibrosis care center on outcomes after lung transplantation for cystic fibrosis

Errol L. Bush, Aravind Krishnan, Alexis P. Chidi, Eric Nolley, Sean Agbor-Enoh, Natalie E. West, Erin Tallarico, Jonathan B. Orens, Jinny Ha, Pali D. Shah, Kathleen J. Ramos, Dorry Segev, Allan Massie, Robert SD Higgins, Christian A. Merlo

Research output: Contribution to journalArticlepeer-review


Background: The purpose of this study was to evaluate outcomes in people with cystic fibrosis (CF) who underwent lung transplant (LT) at a transplant center with an accredited Cystic Fibrosis Care Center (CFCC) in the United States. Methods: We reviewed the Scientific Registry of Transplant Recipients for all adult patients with CF who received a first-time LT from 2005 to 2018. The primary outcome was graft failure. Unadjusted Kaplan-Meier analysis and adjusted multilevel Cox proportional hazards models were used to evaluate outcomes in CF patients undergoing lung transplantation at a CFCC. Results: 2,573 patients with CF underwent a first time LT during the study period. Of the 68 lung transplantation centers, 50 were CFCCs (73.5%). After adjustment for potential confounders, patients who underwent lung transplantation at a hospital with an accredited CFCC had a 33% reduction in risk of death or re-transplantation compared to those transplanted at a hospital without an accredited CFCC (HR: 0.67, 95% CI: 0.56-0.82, p < 0.001). Conclusions: People with CF who undergo LT at a transplant center with a CFCC have improved graft survival and decreased need for re-transplantation compared to those who undergo LT at a non-CFCC, independent of volume.

Original languageEnglish (US)
Pages (from-to)300-307
Number of pages8
JournalJournal of Heart and Lung Transplantation
Issue number3
StatePublished - Mar 2022


  • Cystic Fibrosis
  • lung transplant
  • outcomes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation


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