The effect of sleep on gastrointestinal functioning in common digestive diseases

William C. Orr, Ronnie Fass, Shikha S. Sundaram, Ann O. Scheimann

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Sleep quality and sleep disorders affect symptom manifestation and the pathogenesis of digestive diseases. Sleep is largely regulated by the light–dark cycle and associated circadian rhythms. These occurrences are closely regulated through several mechanisms with direct effects on the gastrointestinal tract. Misalignment of the circadian system is a common cause of sleep complaints, which play an important role in the presentation of many gastrointestinal disorders. This Review will focus on sleep disorders and how these alterations in sleep play an important role in many commonly encountered digestive diseases, such as gastro-oesophageal reflux disease, irritable bowel syndrome, inflammatory bowel disease, and non-alcoholic fatty liver disease. Therapeutic interventions focusing on resolving sleep disorders could optimise treatment and improve quality of life in these patients.

Original languageEnglish (US)
Pages (from-to)616-624
Number of pages9
JournalThe Lancet Gastroenterology and Hepatology
Issue number6
StatePublished - Jun 2020

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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