OBJECTIVE: To study the pressure change of sphincter of Oddi (SO) in acute severe pancreatitis (ASP) and the effect of sandostatin on it. METHODS: Fifteen dogs were used and allocated into 2 groups: ASP untreated group and sandostatin group. The ASP model was prepared by retrograde ductal injection of a mixture of 5% taurocholic acid and autologous bile. SO manometic parameters including basal pressure (BP) and phasic contraction amplitude (PCA) were measured at each time spot before and after the preparation of ASP and after the administration of sandostatin. RESULTS: BP was obviously increased after ASP preparation and sandostatin could significantly decrease the BP of SO in ASP group but not PCA. CONCLUSION: Dysmotility of SO might play an important role in the severity and progression of ASP. Sandostatin may have beneficial effects in the treatment of ASP by decreasing BP of SO.
|Number of pages
|Zhonghua nei ke za zhi [Chinese journal of internal medicine]
|Published - Nov 1999
ASJC Scopus subject areas
- General Medicine