The effect of reserpine on histamine and serotonin

T. Phillip Waalkes; Harriette Coburn; Luther L. Terry

doi:10.1016/0021-8707(59)90018-8

The effect of reserpine on histamine and serotonin

T. Phillip Waalkes, Harriette Coburn, Luther L. Terry

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

1. 1. Reserpine liberates serotonin readily from blood and tissues and liberates histamine from rabbit blood. In guinea pigs and rabbits histamine was found to be released in part from tissues by reserpine but not as readily or to the same extent as serotonin. 2. 2. The evidence suggests a possible similar type of bond for both histamine and serotonin in platelets but a different type of linkage in tissues. 3. 3. The role of reserpine in producing side effects in patients by histamine release is suggested and discussed.

Original language	English (US)
Pages (from-to)	408-414
Number of pages	7
Journal	Journal of Allergy
Volume	30
Issue number	5
DOIs	https://doi.org/10.1016/0021-8707(59)90018-8
State	Published - Jan 1 1959

ASJC Scopus subject areas

General Medicine

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10.1016/0021-8707(59)90018-8

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AU - Coburn, Harriette

AU - Terry, Luther L.

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N2 - 1. 1. Reserpine liberates serotonin readily from blood and tissues and liberates histamine from rabbit blood. In guinea pigs and rabbits histamine was found to be released in part from tissues by reserpine but not as readily or to the same extent as serotonin. 2. 2. The evidence suggests a possible similar type of bond for both histamine and serotonin in platelets but a different type of linkage in tissues. 3. 3. The role of reserpine in producing side effects in patients by histamine release is suggested and discussed.

AB - 1. 1. Reserpine liberates serotonin readily from blood and tissues and liberates histamine from rabbit blood. In guinea pigs and rabbits histamine was found to be released in part from tissues by reserpine but not as readily or to the same extent as serotonin. 2. 2. The evidence suggests a possible similar type of bond for both histamine and serotonin in platelets but a different type of linkage in tissues. 3. 3. The role of reserpine in producing side effects in patients by histamine release is suggested and discussed.

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The effect of reserpine on histamine and serotonin

Abstract

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