The effect of reserpine on histamine and serotonin

T. Phillip Waalkes, Harriette Coburn, Luther L. Terry

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


1. 1. Reserpine liberates serotonin readily from blood and tissues and liberates histamine from rabbit blood. In guinea pigs and rabbits histamine was found to be released in part from tissues by reserpine but not as readily or to the same extent as serotonin. 2. 2. The evidence suggests a possible similar type of bond for both histamine and serotonin in platelets but a different type of linkage in tissues. 3. 3. The role of reserpine in producing side effects in patients by histamine release is suggested and discussed.

Original languageEnglish (US)
Pages (from-to)408-414
Number of pages7
JournalJournal of Allergy
Issue number5
StatePublished - Jan 1 1959

ASJC Scopus subject areas

  • General Medicine


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