The effect of phenobarbital and methylprednisolone on the biotransformation of cyclosporine in the rat

K. L. Brayman; J. Nakamura; A. Naji; C. F. Barker; M. A. Choti; L. M. Shaw

The effect of phenobarbital and methylprednisolone on the biotransformation of cyclosporine in the rat

K. L. Brayman, J. Nakamura, A. Naji, C. F. Barker, M. A. Choti, L. M. Shaw

School of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

To further define the metabolism of CsA, we studied the biotransformation of the drug in male and female rats using high-pressure liquid chromatographic (HPLC) analysis of CsA and primary CsA metabolites in whole blood. Moreover, we characterized the metabolism of Csa following administration of a known hepatic mixed function oxidase inducer, phenobarbital, and a commonly used, clinically relevant immunosuppressive agent, methylprednisolone.

Original language	English (US)
Pages (from-to)	553-556
Number of pages	4
Journal	Transplantation proceedings
Volume	20
Issue number	2 SUPPL. 2
State	Published - Jan 1 1988

ASJC Scopus subject areas

Surgery
Transplantation

Cite this

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abstract = "To further define the metabolism of CsA, we studied the biotransformation of the drug in male and female rats using high-pressure liquid chromatographic (HPLC) analysis of CsA and primary CsA metabolites in whole blood. Moreover, we characterized the metabolism of Csa following administration of a known hepatic mixed function oxidase inducer, phenobarbital, and a commonly used, clinically relevant immunosuppressive agent, methylprednisolone.",

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AU - Brayman, K. L.

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AU - Naji, A.

AU - Barker, C. F.

AU - Choti, M. A.

AU - Shaw, L. M.

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N2 - To further define the metabolism of CsA, we studied the biotransformation of the drug in male and female rats using high-pressure liquid chromatographic (HPLC) analysis of CsA and primary CsA metabolites in whole blood. Moreover, we characterized the metabolism of Csa following administration of a known hepatic mixed function oxidase inducer, phenobarbital, and a commonly used, clinically relevant immunosuppressive agent, methylprednisolone.

AB - To further define the metabolism of CsA, we studied the biotransformation of the drug in male and female rats using high-pressure liquid chromatographic (HPLC) analysis of CsA and primary CsA metabolites in whole blood. Moreover, we characterized the metabolism of Csa following administration of a known hepatic mixed function oxidase inducer, phenobarbital, and a commonly used, clinically relevant immunosuppressive agent, methylprednisolone.

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The effect of phenobarbital and methylprednisolone on the biotransformation of cyclosporine in the rat

Abstract

ASJC Scopus subject areas

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