The effect of leptin on the ventilatory response to hyperoxia

Harald Groeben; Sascha Meier; Robert H. Brown; Christopher P. O'Donnell; Wayne Mitzner; Clarke Tankersley

doi:10.1080/01902140490489144

The effect of leptin on the ventilatory response to hyperoxia

Harald Groeben, Sascha Meier, Robert H. Brown, Christopher P. O'Donnell, Wayne Mitzner, Clarke Tankersley

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Leptin-deficient mice show a blunted response to hypercapnia explained by central nervous system effects. The impact of leptin on peripheral chemoreceptor function is unclear. Therefore, 9 mutant (ob/ob) and 9 wild-type (+/+) mice were exposed to room air or 100% oxygen and respiratory rate (RR) and tidal volume (Vt) were measured. Subsequently, ob/ob mice received either leptin or vehicle and measurements were repeated. Compared to baseline, for +/+ mice, RR decreased significantly by 9.4% ± 3.0% (means ± SD), whereas Vt remained unchanged. Transition from normoxia to hyperoxia did not change RR and Vt in untreated ob/ob mice, whereas after leptin treatment, RR and Vt decreased significantly. Leptin deficiency abolishes the response to hyperoxia, which is restored by leptin replacement. Thus, leptin seems to be influential for a competent peripheral chemoreceptor function.

Original language	English (US)
Pages (from-to)	559-570
Number of pages	12
Journal	Experimental Lung Research
Volume	30
Issue number	7
DOIs	https://doi.org/10.1080/01902140490489144
State	Published - Oct 2004

Keywords

Mice
Peripheral chemoreceptor
Whole body plethysmography

ASJC Scopus subject areas

Molecular Biology
Pulmonary and Respiratory Medicine
Clinical Biochemistry

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10.1080/01902140490489144

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AU - Mitzner, Wayne

AU - Tankersley, Clarke

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The effect of leptin on the ventilatory response to hyperoxia

Abstract

Keywords

ASJC Scopus subject areas

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