The effect of interleukin 38 on inflammation-induced corneal neovascularization

Jiangli Zhu; Jing Zhang; Yan Wang; Jianping Chen; Xiaopeng Li; Xiangling Liu; Eryan Kong; Shao B. Su; Zhongjian Zhang

doi:10.2174/1566524019666190627122655

The effect of interleukin 38 on inflammation-induced corneal neovascularization

Jiangli Zhu, Jing Zhang, Yan Wang, Jianping Chen, Xiaopeng Li, Xiangling Liu, Eryan Kong, Shao B. Su, Zhongjian Zhang

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Angiogenesis is tightly linked to inflammation. Cytokines of interleukin 1 (IL-1) family are key mediators in modulating inflammatory responses. Methods: In this study, we examined the role of IL-38, a member of the IL-1 family, in mediating inflammation-induced angiogenesis. Results: The results showed that the angiogenesis was attenuated by topical administration of IL-38 to the injured corneas in a mouse model of alkali-induced corneal neovascularization (CNV). Further study showed that the expression of inflammatory cytokines TNF-α, IL-6, IL-8 and IL-1β was decreased in the IL-38-treated corneas. Moreover, the angiogenic activities including the proliferation, migration and tube formation of human retinal endothelial cells were reduced by IL-38 treatment in vitro. Conclusion: The data indicate that IL-38 modulates inflammation-induced angiogenesis.

Original language	English (US)
Pages (from-to)	589-596
Number of pages	8
Journal	Current Molecular Medicine
Volume	19
Issue number	8
DOIs	https://doi.org/10.2174/1566524019666190627122655
State	Published - 2019
Externally published	Yes

Keywords

Angiogenesis
Cytokine
IL-38
Inflammation
Interleukin
Neovascularization

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology

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10.2174/1566524019666190627122655

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@article{6d20f33c89644fffa5f13b671b838393,

title = "The effect of interleukin 38 on inflammation-induced corneal neovascularization",

abstract = "Background: Angiogenesis is tightly linked to inflammation. Cytokines of interleukin 1 (IL-1) family are key mediators in modulating inflammatory responses. Methods: In this study, we examined the role of IL-38, a member of the IL-1 family, in mediating inflammation-induced angiogenesis. Results: The results showed that the angiogenesis was attenuated by topical administration of IL-38 to the injured corneas in a mouse model of alkali-induced corneal neovascularization (CNV). Further study showed that the expression of inflammatory cytokines TNF-α, IL-6, IL-8 and IL-1β was decreased in the IL-38-treated corneas. Moreover, the angiogenic activities including the proliferation, migration and tube formation of human retinal endothelial cells were reduced by IL-38 treatment in vitro. Conclusion: The data indicate that IL-38 modulates inflammation-induced angiogenesis.",

keywords = "Angiogenesis, Cytokine, IL-38, Inflammation, Interleukin, Neovascularization",

author = "Jiangli Zhu and Jing Zhang and Yan Wang and Jianping Chen and Xiaopeng Li and Xiangling Liu and Eryan Kong and Su, {Shao B.} and Zhongjian Zhang",

note = "Funding Information: This project was supported in part by the grants from the National Natural Science Foundation of China (31471122). Publisher Copyright: {\textcopyright} 2019 Bentham Science Publishers.",

year = "2019",

doi = "10.2174/1566524019666190627122655",

language = "English (US)",

volume = "19",

pages = "589--596",

journal = "Current Molecular Medicine",

issn = "1566-5240",

publisher = "Bentham Science Publishers B.V.",

number = "8",

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TY - JOUR

T1 - The effect of interleukin 38 on inflammation-induced corneal neovascularization

AU - Zhu, Jiangli

AU - Zhang, Jing

AU - Wang, Yan

AU - Chen, Jianping

AU - Li, Xiaopeng

AU - Liu, Xiangling

AU - Kong, Eryan

AU - Su, Shao B.

AU - Zhang, Zhongjian

PY - 2019

Y1 - 2019

N2 - Background: Angiogenesis is tightly linked to inflammation. Cytokines of interleukin 1 (IL-1) family are key mediators in modulating inflammatory responses. Methods: In this study, we examined the role of IL-38, a member of the IL-1 family, in mediating inflammation-induced angiogenesis. Results: The results showed that the angiogenesis was attenuated by topical administration of IL-38 to the injured corneas in a mouse model of alkali-induced corneal neovascularization (CNV). Further study showed that the expression of inflammatory cytokines TNF-α, IL-6, IL-8 and IL-1β was decreased in the IL-38-treated corneas. Moreover, the angiogenic activities including the proliferation, migration and tube formation of human retinal endothelial cells were reduced by IL-38 treatment in vitro. Conclusion: The data indicate that IL-38 modulates inflammation-induced angiogenesis.

AB - Background: Angiogenesis is tightly linked to inflammation. Cytokines of interleukin 1 (IL-1) family are key mediators in modulating inflammatory responses. Methods: In this study, we examined the role of IL-38, a member of the IL-1 family, in mediating inflammation-induced angiogenesis. Results: The results showed that the angiogenesis was attenuated by topical administration of IL-38 to the injured corneas in a mouse model of alkali-induced corneal neovascularization (CNV). Further study showed that the expression of inflammatory cytokines TNF-α, IL-6, IL-8 and IL-1β was decreased in the IL-38-treated corneas. Moreover, the angiogenic activities including the proliferation, migration and tube formation of human retinal endothelial cells were reduced by IL-38 treatment in vitro. Conclusion: The data indicate that IL-38 modulates inflammation-induced angiogenesis.

KW - Angiogenesis

KW - Cytokine

KW - IL-38

KW - Inflammation

KW - Interleukin

KW - Neovascularization

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SN - 1566-5240

VL - 19

SP - 589

EP - 596

JO - Current Molecular Medicine

JF - Current Molecular Medicine

IS - 8

ER -

The effect of interleukin 38 on inflammation-induced corneal neovascularization

Abstract

Keywords

ASJC Scopus subject areas

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