The Effect of HIV-Centered Obstetric Care on Perinatal Outcomes among a Cohort of Women Living with HIV

Anna M. Powell, Julia M. DeVita, Amartha Ogburu-Ogbonnaya, Andrea Peterson, Gweneth B. Lazenby

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: Elimination of perinatal transmission is possible but limited by missed care opportunities. Our objective was to investigate the effects of HIV-centered obstetric care (HCC) on missed care opportunities and perinatal HIV transmission in 2 obstetric cohorts at our institution from 2000 to 2014. Methods: This was a retrospective cohort study of HIV-exposed mother-infant pairs delivering from 2000 to 2014, analyzed according to SQUIRE 2.0 (Standards for Quality Improvement Reporting Excellence) guidelines. Before 2009, women received care in high-risk obstetric care (HRC); subsequently, an HCC service was established. Women who received HRC vs HCC obstetric care were compared to determine differences in maternal and neonatal outcomes. Continuous variables were compared with Student t test and Wilcoxon rank sum tests. Categorical variables were compared using χ 2 test and Fisher exact test. Logistic regression analyses were performed to determine factors associated with outcomes of interest. Results: Over 14 years, 161 women delivered 217 HIV-exposed infants; 78 (36%) women received HCC. Two perinatal HIV transmissions (1.5%) occurred in HRC group compared with none in the HCC group (P = 0.3). Women in HCC were more likely to have HIV RNA viral load <1000 copies per milliliter at delivery (12% vs 26%, P = 0.02), have a contraception plan before delivery (93% vs 60%, P < 0.001), return for postpartum evaluation (80% vs 63%, P = 0.01), and have undetectable HIV viral load postpartum (50 copies per milliliter vs 2067, P < 0.0001). Conclusions: HCC can potentially reduce the risk of perinatal HIV transmission by improving maternal virologic control during pregnancy and postpartum and increasing postpartum contraceptive use.

Original languageEnglish (US)
Pages (from-to)431-438
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number4
StatePublished - Aug 1 2017
Externally publishedYes


  • HIV
  • elimination of perinatal transmission
  • long-acting reversible contraception
  • missed care opportunities
  • prenatal care

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)


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