The effect of cyclic AMP on glycogenolysis and glycolysis in human platelets

Philip D. Zieve; Morton Schmukler

doi:10.1016/0304-4165(71)90008-0

The effect of cyclic AMP on glycogenolysis and glycolysis in human platelets

Philip D. Zieve, Morton Schmukler

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Cyclic AMP increased glycogenolysis and stimulated phosphorylase in sonicates of human platelets. Paradoxically, lactate formation formation was reduced by cyclic AMP in platelet lysates as well as by dibutyryl cyclic AMP and prostaglandin E₁. This decrease in lactate formation appears to be mediated by an inhibition of phosphofructokinase. These metabolic effects of cyclic AMP may be related to the inhibition of aggregation of platelets by this compound and by agents which stimulate its production.

Original language	English (US)
Pages (from-to)	280-284
Number of pages	5
Journal	BBA - General Subjects
Volume	252
Issue number	2
DOIs	https://doi.org/10.1016/0304-4165(71)90008-0
State	Published - Nov 12 1971

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology

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10.1016/0304-4165(71)90008-0

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abstract = "Cyclic AMP increased glycogenolysis and stimulated phosphorylase in sonicates of human platelets. Paradoxically, lactate formation formation was reduced by cyclic AMP in platelet lysates as well as by dibutyryl cyclic AMP and prostaglandin E1. This decrease in lactate formation appears to be mediated by an inhibition of phosphofructokinase. These metabolic effects of cyclic AMP may be related to the inhibition of aggregation of platelets by this compound and by agents which stimulate its production.",

author = "Zieve, {Philip D.} and Morton Schmukler",

note = "Funding Information: grant, HE-o9Io2, from the National Heart",

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AU - Zieve, Philip D.

AU - Schmukler, Morton

N1 - Funding Information: grant, HE-o9Io2, from the National Heart

PY - 1971/11/12

Y1 - 1971/11/12

N2 - Cyclic AMP increased glycogenolysis and stimulated phosphorylase in sonicates of human platelets. Paradoxically, lactate formation formation was reduced by cyclic AMP in platelet lysates as well as by dibutyryl cyclic AMP and prostaglandin E1. This decrease in lactate formation appears to be mediated by an inhibition of phosphofructokinase. These metabolic effects of cyclic AMP may be related to the inhibition of aggregation of platelets by this compound and by agents which stimulate its production.

AB - Cyclic AMP increased glycogenolysis and stimulated phosphorylase in sonicates of human platelets. Paradoxically, lactate formation formation was reduced by cyclic AMP in platelet lysates as well as by dibutyryl cyclic AMP and prostaglandin E1. This decrease in lactate formation appears to be mediated by an inhibition of phosphofructokinase. These metabolic effects of cyclic AMP may be related to the inhibition of aggregation of platelets by this compound and by agents which stimulate its production.

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The effect of cyclic AMP on glycogenolysis and glycolysis in human platelets

Abstract

ASJC Scopus subject areas

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