The effect of BCG on extravascular mononuclear cell accumulation In vivo

R. J. Perper; A. L. Oronsky; M. Sanda

doi:10.1002/ijc.2910170517

The effect of BCG on extravascular mononuclear cell accumulation In vivo

R. J. Perper, A. L. Oronsky, M. Sanda

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

BCG injection produces an increased accumulation of adoptively transferred ⁵¹Cr‐labelled mononuclear cells at the site of inflammatory reactions in rats by two mechanisms. Systemic immunization induced a population of “activated” cells which, compared with controls, had an increased life span in the circulation after transfer and migrated in increased numbers to a chemotactic stimulus. These cells also were found in significantly greater than normal levels in the liver. In addition, local injection of BCG selectively attracted adoptively transferred mononuclear cells. These mechanisms help to explain local mononuclear cell accumulation which accompanies tumor rejection following intralesional or systemic BCG immunization.

Original language	English (US)
Pages (from-to)	670-677
Number of pages	8
Journal	International Journal of Cancer
Volume	17
Issue number	5
DOIs	https://doi.org/10.1002/ijc.2910170517
State	Published - May 15 1976

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "The effect of BCG on extravascular mononuclear cell accumulation In vivo",

abstract = "BCG injection produces an increased accumulation of adoptively transferred 51Cr‐labelled mononuclear cells at the site of inflammatory reactions in rats by two mechanisms. Systemic immunization induced a population of “activated” cells which, compared with controls, had an increased life span in the circulation after transfer and migrated in increased numbers to a chemotactic stimulus. These cells also were found in significantly greater than normal levels in the liver. In addition, local injection of BCG selectively attracted adoptively transferred mononuclear cells. These mechanisms help to explain local mononuclear cell accumulation which accompanies tumor rejection following intralesional or systemic BCG immunization.",

author = "Perper, {R. J.} and Oronsky, {A. L.} and M. Sanda",

year = "1976",

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AU - Oronsky, A. L.

AU - Sanda, M.

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Y1 - 1976/5/15

N2 - BCG injection produces an increased accumulation of adoptively transferred 51Cr‐labelled mononuclear cells at the site of inflammatory reactions in rats by two mechanisms. Systemic immunization induced a population of “activated” cells which, compared with controls, had an increased life span in the circulation after transfer and migrated in increased numbers to a chemotactic stimulus. These cells also were found in significantly greater than normal levels in the liver. In addition, local injection of BCG selectively attracted adoptively transferred mononuclear cells. These mechanisms help to explain local mononuclear cell accumulation which accompanies tumor rejection following intralesional or systemic BCG immunization.

AB - BCG injection produces an increased accumulation of adoptively transferred 51Cr‐labelled mononuclear cells at the site of inflammatory reactions in rats by two mechanisms. Systemic immunization induced a population of “activated” cells which, compared with controls, had an increased life span in the circulation after transfer and migrated in increased numbers to a chemotactic stimulus. These cells also were found in significantly greater than normal levels in the liver. In addition, local injection of BCG selectively attracted adoptively transferred mononuclear cells. These mechanisms help to explain local mononuclear cell accumulation which accompanies tumor rejection following intralesional or systemic BCG immunization.

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The effect of BCG on extravascular mononuclear cell accumulation In vivo

Abstract

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