Abstract
A group of 22 hirsute women was treated with a combination of 0.030 mg of ethinylestradiol and 0.150 mg of desogestrel (EE-DG) for 6 or 12 months. After 6 months the hair growth was decreased in 17 patients. There was a significant decrease in testosterone/sex hormone binding globulin (T/SHBG) ratio and serum dehydroepiandrosterone sulphate (DHEAS) levels. The changes in the hirsutism and the T/SHBG ratio showed correlation (rho 0.36, P < 0.05). The patient groups with the best and the poorest clinical response differed in terms of summed changes in the T/SHBG ratio and DHEAS. These findings suggest that the therapeutic effect of the EE-DG is based on combined changes in the related hormone levels.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 361-368 |
| Number of pages | 8 |
| Journal | International Journal of Gynecology and Obstetrics |
| Volume | 24 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 1986 |
| Externally published | Yes |
Keywords
- Androgens
- Dehydroepiandrosterone sulphate
- Desogestrel
- Ethinylestradiol
- Hirsutism
- Oral contraceptives
ASJC Scopus subject areas
- Obstetrics and Gynecology
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