The effect of alum concentration on the repository and adjuvant properties of alum-precipitated antigens

Robert S. Holzman; Philip S. Norman

doi:10.1016/0021-8707(66)90045-1

The effect of alum concentration on the repository and adjuvant properties of alum-precipitated antigens

Robert S. Holzman, Philip S. Norman

School of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The alum-precipitated pyridine extracts of allergenic materials recently introduced for desensitization contain much more alum in the precipitate than is commonly used in most vaccines. A study in rabbits of the relationship of alum concentration to antigen retention and antibody responses showed that an increase in alum concentration to 30 mg. per milliliter resulted in more prolonged retention of antigen at the site of injection than is observed with mineral oil-Arlacel emulsions. When used to elicit secondary immune responses, these very persistent precipitates showed little adjwvant effect and gave antibody responses only slightly better than saline solutions of antigen. Such alum precipitates, however, may provide an even greater safety factor than oil emulsions to prevent systemic reaction to toxic antigens.

Original language	English (US)
Pages (from-to)	65-73
Number of pages	9
Journal	Journal of Allergy
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/0021-8707(66)90045-1
State	Published - Aug 1966

ASJC Scopus subject areas

Medicine(all)

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10.1016/0021-8707(66)90045-1

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title = "The effect of alum concentration on the repository and adjuvant properties of alum-precipitated antigens",

abstract = "The alum-precipitated pyridine extracts of allergenic materials recently introduced for desensitization contain much more alum in the precipitate than is commonly used in most vaccines. A study in rabbits of the relationship of alum concentration to antigen retention and antibody responses showed that an increase in alum concentration to 30 mg. per milliliter resulted in more prolonged retention of antigen at the site of injection than is observed with mineral oil-Arlacel emulsions. When used to elicit secondary immune responses, these very persistent precipitates showed little adjwvant effect and gave antibody responses only slightly better than saline solutions of antigen. Such alum precipitates, however, may provide an even greater safety factor than oil emulsions to prevent systemic reaction to toxic antigens.",

author = "Holzman, {Robert S.} and Norman, {Philip S.}",

note = "Funding Information: From the Allergy and Infectious University and Hospital, Baltimore, Supported by a training grant of Allergy and Infectious Disease. Received for publication Aug. *Research Career Development Disease. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

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AU - Norman, Philip S.

N1 - Funding Information: From the Allergy and Infectious University and Hospital, Baltimore, Supported by a training grant of Allergy and Infectious Disease. Received for publication Aug. *Research Career Development Disease. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

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AB - The alum-precipitated pyridine extracts of allergenic materials recently introduced for desensitization contain much more alum in the precipitate than is commonly used in most vaccines. A study in rabbits of the relationship of alum concentration to antigen retention and antibody responses showed that an increase in alum concentration to 30 mg. per milliliter resulted in more prolonged retention of antigen at the site of injection than is observed with mineral oil-Arlacel emulsions. When used to elicit secondary immune responses, these very persistent precipitates showed little adjwvant effect and gave antibody responses only slightly better than saline solutions of antigen. Such alum precipitates, however, may provide an even greater safety factor than oil emulsions to prevent systemic reaction to toxic antigens.

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The effect of alum concentration on the repository and adjuvant properties of alum-precipitated antigens

Abstract

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