The effect of acth administration on plasma testosterone, dihydrotestosterone and serum lh concentrations in normal men

Inese Z. Beitins; Francis Bayard; Avinoam Kowarski; Claude J. Migeon

doi:10.1016/0039-128X(73)90044-5

The effect of acth administration on plasma testosterone, dihydrotestosterone and serum lh concentrations in normal men

Inese Z. Beitins
, Francis Bayard
, Avinoam Kowarski
, Claude J. Migeon

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Plasma cortisol (F), testosterone (T), dihydrotestosterone (DHT) and serum luteinizing hormone (LH) concentrations were measured in 8 normal young men at 8 AM on two control days. Exogenous adrenocorticotrophin (ACTH) 20 U.S.P. units per m² of body surface area every 12 or 6 hours was administered intramuscularly for 4 days. Twenty-four hours after starting ACTH administration, the plasma T and DHT concentrations were significantly lower than those of the control days on a paired t test. No significant change in serum LH concentration could be demonstrated. Similar results were observed after 48, 72 and 96 hours of ACTH stimulation.

Original language	English (US)
Pages (from-to)	553-563
Number of pages	11
Journal	Steroids
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/0039-128X(73)90044-5
State	Published - Apr 1973
Externally published	Yes

Keywords

17β-hydroxy-5α-androstan-3-one
4-androstene-3,17-dione
Androstenedione (Δ)
Dihydrotestosterone (DHT)

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology
Pharmacology
Clinical Biochemistry
Organic Chemistry

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10.1016/0039-128X(73)90044-5

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@article{611d71e70904484f8087ae8b070014dd,

title = "The effect of acth administration on plasma testosterone, dihydrotestosterone and serum lh concentrations in normal men",

abstract = "Plasma cortisol (F), testosterone (T), dihydrotestosterone (DHT) and serum luteinizing hormone (LH) concentrations were measured in 8 normal young men at 8 AM on two control days. Exogenous adrenocorticotrophin (ACTH) 20 U.S.P. units per m2 of body surface area every 12 or 6 hours was administered intramuscularly for 4 days. Twenty-four hours after starting ACTH administration, the plasma T and DHT concentrations were significantly lower than those of the control days on a paired t test. No significant change in serum LH concentration could be demonstrated. Similar results were observed after 48, 72 and 96 hours of ACTH stimulation.",

keywords = "17β-hydroxy-5α-androstan-3-one, 4-androstene-3,17-dione, Androstenedione (Δ), Dihydrotestosterone (DHT)",

author = "Beitins, \{Inese Z.\} and Francis Bayard and Avinoam Kowarski and Migeon, \{Claude J.\}",

note = "Funding Information: This investigation was supported by Research Grant AM-00180, Traineeship Grant TOl-AM-5219 and Research Career Award 5 K06-AM-21,855 (C, J.M.) from the United States Public Health Service. Dr, Bayard was supported by the Ministere des Affaires Etrangeres of France.",

year = "1973",

month = apr,

doi = "10.1016/0039-128X(73)90044-5",

language = "English (US)",

volume = "21",

pages = "553--563",

journal = "Steroids",

issn = "0039-128X",

publisher = "Elsevier Inc.",

number = "4",

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TY - JOUR

T1 - The effect of acth administration on plasma testosterone, dihydrotestosterone and serum lh concentrations in normal men

AU - Beitins, Inese Z.

AU - Bayard, Francis

AU - Kowarski, Avinoam

AU - Migeon, Claude J.

N1 - Funding Information: This investigation was supported by Research Grant AM-00180, Traineeship Grant TOl-AM-5219 and Research Career Award 5 K06-AM-21,855 (C, J.M.) from the United States Public Health Service. Dr, Bayard was supported by the Ministere des Affaires Etrangeres of France.

PY - 1973/4

Y1 - 1973/4

N2 - Plasma cortisol (F), testosterone (T), dihydrotestosterone (DHT) and serum luteinizing hormone (LH) concentrations were measured in 8 normal young men at 8 AM on two control days. Exogenous adrenocorticotrophin (ACTH) 20 U.S.P. units per m2 of body surface area every 12 or 6 hours was administered intramuscularly for 4 days. Twenty-four hours after starting ACTH administration, the plasma T and DHT concentrations were significantly lower than those of the control days on a paired t test. No significant change in serum LH concentration could be demonstrated. Similar results were observed after 48, 72 and 96 hours of ACTH stimulation.

AB - Plasma cortisol (F), testosterone (T), dihydrotestosterone (DHT) and serum luteinizing hormone (LH) concentrations were measured in 8 normal young men at 8 AM on two control days. Exogenous adrenocorticotrophin (ACTH) 20 U.S.P. units per m2 of body surface area every 12 or 6 hours was administered intramuscularly for 4 days. Twenty-four hours after starting ACTH administration, the plasma T and DHT concentrations were significantly lower than those of the control days on a paired t test. No significant change in serum LH concentration could be demonstrated. Similar results were observed after 48, 72 and 96 hours of ACTH stimulation.

KW - 17β-hydroxy-5α-androstan-3-one

KW - 4-androstene-3,17-dione

KW - Androstenedione (Δ)

KW - Dihydrotestosterone (DHT)

UR - https://www.scopus.com/pages/publications/0015605512

UR - https://www.scopus.com/pages/publications/0015605512#tab=citedBy

U2 - 10.1016/0039-128X(73)90044-5

DO - 10.1016/0039-128X(73)90044-5

M3 - Article

C2 - 4349242

AN - SCOPUS:0015605512

SN - 0039-128X

VL - 21

SP - 553

EP - 563

JO - Steroids

JF - Steroids

IS - 4

ER -

The effect of acth administration on plasma testosterone, dihydrotestosterone and serum lh concentrations in normal men

Abstract

Keywords

ASJC Scopus subject areas

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