Abstract
Plasma cortisol (F), testosterone (T), dihydrotestosterone (DHT) and serum luteinizing hormone (LH) concentrations were measured in 8 normal young men at 8 AM on two control days. Exogenous adrenocorticotrophin (ACTH) 20 U.S.P. units per m2 of body surface area every 12 or 6 hours was administered intramuscularly for 4 days. Twenty-four hours after starting ACTH administration, the plasma T and DHT concentrations were significantly lower than those of the control days on a paired t test. No significant change in serum LH concentration could be demonstrated. Similar results were observed after 48, 72 and 96 hours of ACTH stimulation.
Original language | English (US) |
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Pages (from-to) | 553-563 |
Number of pages | 11 |
Journal | Steroids |
Volume | 21 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1973 |
Externally published | Yes |
Keywords
- 17β-hydroxy-5α-androstan-3-one
- 4-androstene-3,17-dione
- Androstenedione (Δ)
- Dihydrotestosterone (DHT)
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Endocrinology
- Pharmacology
- Clinical Biochemistry
- Organic Chemistry