The early diagnosis of ischemic necrosis of bone

T. M. Zizic, C. Marcoux, D. S. Hungerford, M. B. Stevens

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


One hundred sixty‐nine patients with radio‐graphic or histologic evidence of ischemic necrosis of bone (INB) were evaluated. Ninety‐nine (59%) of the 169 patients had multiple sites of INB, with 310 bones affected. Two hundred sixty‐three (85%) of the 310 ischemic bones were symptomatic. Routine radiography produced negative findings in 58 (20%) of the bones with histologically confirmed INB. Results of hemodynamic studies, including baseline bone marrow pressure, saline stress test, and/or intraosseous venography, were abnormal in 243 (94%) of 259 ischemic bones so evaluated. Most importantly, hemodynamic studies detected 51 (93%) of the 55 bones that were radiographically normal but had histologically confirmed INB.

Original languageEnglish (US)
Pages (from-to)1177-1186
Number of pages10
JournalArthritis & Rheumatism
Issue number10
StatePublished - Oct 1986
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)


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