The drug resistance-related protein LRP is the human major vault protein

George L. Scheffer, Peter L J Wijngaard, Marcel J. Flens, Miguel A. Izquierdo, Marilyn L. Slovak, Herbert M. Pinedo, Chris J L M Meijer, Hans C. Clevers, Rik J. Scheper

Research output: Contribution to journalArticlepeer-review

565 Scopus citations


Multidrug-resistant cancer cells frequently overexpress the 110-kD LRP protein (originally named Lung Resistance-related Protein). LRP overexpression has been found to predict a poor response to chemotherapy in acute myeloid leukaemia and ovarian carcinoma. We describe the cloning and chromosome localization of the gene coding for this novel protein. The deduced LRP amino acid sequence shows 87.7% identity with the 104-kD rat major vault protein. Vaults are multi subunit structures that may be involved in nucleo-cytoplasmic transport. The LRP gene is located on chromosome 16, close to the genes coding for multidrug resistance-associated protein and protein kinase c-β, and may mediate drug resistance, perhaps via a transport process.

Original languageEnglish (US)
Pages (from-to)578-582
Number of pages5
JournalNature Medicine
Issue number6
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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