Abstract
The prostate of castrated dogs following treatment with testosterone, dihydrotestosterone and androstanediol combined with 17-β-estradiol application was analyzed by light microscopic stereology. In all three groups there is a statistically significant increase of prostatic volume and weight. There is a statistically significant increase of the relative and absolute volume of the glandular as well as of the stromal part. Seen by the absolute data there is only a statistically significant increase of the volumetric amount of the smooth muscle cells in the dihydrotestosterone and 17-β-estradiol treated animals. Regarding tissue distribution there is no difference between the controls and the castrated testosterone and 17-β-estradiol treated animals. Regarding the stromal part, there is no statistically significant difference between the testosterone and 17-β-estradiol treated group and the control animals. In the androstanediol and 17-β-estradiol group there is a double and in the dihydrotestosterone and 17-β-estradiol group a four-fold increase of the stromal part. The synergistic effect of estrogens and androgens on the growth of both parts of the dog prostate — the glandular and stromal compartment — is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 347-361 |
| Number of pages | 15 |
| Journal | Pathology Research and Practice |
| Volume | 166 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - 1980 |
| Externally published | Yes |
Keywords
- Androgens
- Castration
- Dog
- Estrogens
- Morphometry
- Prostata
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Cell Biology