TY - JOUR
T1 - The dietary fructose
T2 - Vitamin C intake ratio is associated with hyperuricemia in african-american adults
AU - Zheng, Zihe
AU - Harman, Jane L.
AU - Coresh, Josef
AU - Köttgen, Anna
AU - McAdams-DeMarco, Mara A.
AU - Correa, Adolfo
AU - Young, Bessie A.
AU - Katz, Ronit
AU - Rebholz, Casey M.
N1 - Funding Information:
The Jackson Heart Study is supported by contracts from the National Heart, Lung, and Blood Institute and the National Institute on Minority Health and Health Disparities (HHSN268201300046C, HHSN268201300047C, HHSN268201300048C, HHSN268201300049C, and HHSN268201300050C). CMR is supported by a Mentored Research Scientist Development Award from the National Institute of Diabetes and Digestive and Kidney Diseases (K01 DK107782). BAY is supported in part by funds from the National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK102134) and the Veterans Affairs Puget Sound Health Care System.
Publisher Copyright:
©2018 American Society for Nutrition.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Background: A high fructose intake has been shown to be associated with increased serum urate concentration, whereas ascorbate (vitamin C) may lower serum urate by competing with urate for renal reabsorption. Objective:We assessed the combined association, as the fructose:vitamin C intake ratio, and the separate associations of dietary fructose and vitamin C intakes on prevalent hyperuricemia. Methods:We conducted cross-sectional analyses of dietary intakes of fructose and vitamin C and serum urate concentrations among Jackson Heart Study participants, a cohort of African Americans in Jackson, Mississippi, aged 21-91 y. In the analytic sample (n = 4576), multivariable logistic regression was used to examine the separate associations of dietary intakes of fructose and vitamin C and the fructose:vitamin C intake ratio with prevalent hyperuricemia (serum urate >7 mg/dL), after adjusting for age, sex, smoking, waist circumference, systolic blood pressure, estimated glomerular filtration rate, diuretic medication use, vitamin C supplement use, total energy intake, alcohol consumption, and dietary intake of animal protein. Analyses for individual dietary factors (vitamin C, fructose) were adjusted for the other dietary factor. Results: In the fully adjusted model, there were 17% greater odds of hyperuricemia associated with a doubling of the fructose:vitamin C intake ratio (OR: 1.17; 95% CI: 1.08, 1.28), 20% greater odds associated with a doubling of fructose intake (OR: 1.20; 95% CI: 1.08, 1.34), and 13%lower odds associated with a doubling of vitamin C intake (OR: 0.87; 95% CI: 0.78, 0.97). Dietary fructose and the fructose:vitamin C intake ratiowere more strongly associated with hyperuricemia among men than women (P-interaction ≤ 0.04). Conclusion: Dietary intakes of fructose and vitamin C are associated with prevalent hyperuricemia in a community-based population of African Americans.
AB - Background: A high fructose intake has been shown to be associated with increased serum urate concentration, whereas ascorbate (vitamin C) may lower serum urate by competing with urate for renal reabsorption. Objective:We assessed the combined association, as the fructose:vitamin C intake ratio, and the separate associations of dietary fructose and vitamin C intakes on prevalent hyperuricemia. Methods:We conducted cross-sectional analyses of dietary intakes of fructose and vitamin C and serum urate concentrations among Jackson Heart Study participants, a cohort of African Americans in Jackson, Mississippi, aged 21-91 y. In the analytic sample (n = 4576), multivariable logistic regression was used to examine the separate associations of dietary intakes of fructose and vitamin C and the fructose:vitamin C intake ratio with prevalent hyperuricemia (serum urate >7 mg/dL), after adjusting for age, sex, smoking, waist circumference, systolic blood pressure, estimated glomerular filtration rate, diuretic medication use, vitamin C supplement use, total energy intake, alcohol consumption, and dietary intake of animal protein. Analyses for individual dietary factors (vitamin C, fructose) were adjusted for the other dietary factor. Results: In the fully adjusted model, there were 17% greater odds of hyperuricemia associated with a doubling of the fructose:vitamin C intake ratio (OR: 1.17; 95% CI: 1.08, 1.28), 20% greater odds associated with a doubling of fructose intake (OR: 1.20; 95% CI: 1.08, 1.34), and 13%lower odds associated with a doubling of vitamin C intake (OR: 0.87; 95% CI: 0.78, 0.97). Dietary fructose and the fructose:vitamin C intake ratiowere more strongly associated with hyperuricemia among men than women (P-interaction ≤ 0.04). Conclusion: Dietary intakes of fructose and vitamin C are associated with prevalent hyperuricemia in a community-based population of African Americans.
KW - Dietary intake
KW - Fructose
KW - Hyperuricemia
KW - Urate
KW - Vitamin C
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UR - http://www.scopus.com/inward/citedby.url?scp=85050587324&partnerID=8YFLogxK
U2 - 10.1093/jn/nxx054
DO - 10.1093/jn/nxx054
M3 - Article
C2 - 29546301
AN - SCOPUS:85050587324
SN - 0022-3166
VL - 148
SP - 419
EP - 426
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 3
ER -