The dexamethasone suppression test and mood following stroke

J. R. Lipsey, R. G. Robinson, G. D. Pearlson, K. Rao, T. R. Price

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


Dexamethasone suppression tests (DSTs) were given to 65 acute and chronic stroke patients. For patients who had had a stroke less than 1 year earlier, nonsuppression on the DST was significantly associated with the presence of poststroke depression. The authors, who used the DSM-III symptom criteria for major depression, found that DST sensitivity was 67% but specificity was only 70%. False positive tests in the stroke patients seemed related to large lesion volume. The DST, although of limited clinical utility in this population because of false positive tests, may help define more homogeneous subtypes of poststroke depression for research.

Original languageEnglish (US)
Pages (from-to)318-323
Number of pages6
JournalAmerican Journal of Psychiatry
Issue number3
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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