The development of neurobiological models for cognitive decline in aging

Michela Gallagher, T. Michael Gill, Mark G. Baxter, David J. Bucci

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Neurobiological models are important for identifying the effects of aging that contribute to cognitive decline and for developing interventions to either prevent those changes or restore more optimal function. As a starting point, this paper considers one type of approach using cholinergic deficiency within the hippocampal system as a model for age-related spatial learning impairment. It is suggested that this approach, based on producing a target lesion in the brain, is inadequate for investigating the aging process. As an alternative, a systems-level approach to the development of more useful and accurate models of neurobiological aging is advocated.

Original languageEnglish (US)
Pages (from-to)351-358
Number of pages8
JournalSeminars in Neuroscience
Issue number6
StatePublished - Dec 1994
Externally publishedYes


  • Aging
  • Cholinergic
  • Hippocampus
  • Rat
  • Spatial

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'The development of neurobiological models for cognitive decline in aging'. Together they form a unique fingerprint.

Cite this