TY - JOUR
T1 - The damage response framework and infection prevention
T2 - From concept to bedside
AU - Godbout, Emily J.
AU - Madaline, Theresa
AU - Casadevall, Arturo
AU - Bearman, Gonzalo
AU - Pirofski, Liise Anne
N1 - Publisher Copyright:
© 2020 by The Society for Healthcare Epidemiology of America.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Hospital-acquired infections remain a common cause of morbidity and mortality despite advances in infection prevention through use of bundles, environmental cleaning, antimicrobial stewardship, and other best practices. Current prevention strategies and further hospital-acquired infection reduction are limited by lack of recognition of the role that host-microbe interactions play in susceptibility and by the inability to analyze multiple risk factors in real time to accurately predict the likelihood of a hospital-acquired infection before it occurs and to inform medical decision making. Herein, we examine the value of incorporating the damage-response framework and host attributes that determine susceptibility to infectious diseases known by the acronym MISTEACHING (ie, microbiome, immunity, sex, temperature, environment, age, chance, history, inoculum, nutrition, genetics) into infection prevention strategies using machine learning to drive decision support and patient-specific interventions.
AB - Hospital-acquired infections remain a common cause of morbidity and mortality despite advances in infection prevention through use of bundles, environmental cleaning, antimicrobial stewardship, and other best practices. Current prevention strategies and further hospital-acquired infection reduction are limited by lack of recognition of the role that host-microbe interactions play in susceptibility and by the inability to analyze multiple risk factors in real time to accurately predict the likelihood of a hospital-acquired infection before it occurs and to inform medical decision making. Herein, we examine the value of incorporating the damage-response framework and host attributes that determine susceptibility to infectious diseases known by the acronym MISTEACHING (ie, microbiome, immunity, sex, temperature, environment, age, chance, history, inoculum, nutrition, genetics) into infection prevention strategies using machine learning to drive decision support and patient-specific interventions.
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U2 - 10.1017/ice.2019.354
DO - 10.1017/ice.2019.354
M3 - Review article
C2 - 31915082
AN - SCOPUS:85077738461
SN - 0899-823X
VL - 41
SP - 337
EP - 341
JO - Infection control and hospital epidemiology
JF - Infection control and hospital epidemiology
IS - 3
ER -