The damage response framework and infection prevention: From concept to bedside

Emily J. Godbout, Theresa Madaline, Arturo Casadevall, Gonzalo Bearman, Liise Anne Pirofski

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Hospital-acquired infections remain a common cause of morbidity and mortality despite advances in infection prevention through use of bundles, environmental cleaning, antimicrobial stewardship, and other best practices. Current prevention strategies and further hospital-acquired infection reduction are limited by lack of recognition of the role that host-microbe interactions play in susceptibility and by the inability to analyze multiple risk factors in real time to accurately predict the likelihood of a hospital-acquired infection before it occurs and to inform medical decision making. Herein, we examine the value of incorporating the damage-response framework and host attributes that determine susceptibility to infectious diseases known by the acronym MISTEACHING (ie, microbiome, immunity, sex, temperature, environment, age, chance, history, inoculum, nutrition, genetics) into infection prevention strategies using machine learning to drive decision support and patient-specific interventions.

Original languageEnglish (US)
Pages (from-to)337-341
Number of pages5
JournalInfection control and hospital epidemiology
Issue number3
StatePublished - Mar 1 2020

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


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