The current role of chemotherapy in metastatic hormone-refractory prostate cancer

Daniel P. Petrylak, Matthew R. Smith, Michael A. Carducci

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


Since the publication of the Southwest Oncology Group (SWOG) 99-16 and TAX 327 studies, which demonstrated a survival benefit for docetaxel-based therapy, clinicians for the first time have a therapy to offer men with metastatic prostate cancer that is not merely palliative in its effects. Phase 2 and phase 3 trials are now building on the findings of SWOG 99-16 and TAX 327 by evaluating the potential of combination taxane-based therapies, such as docetaxel plus high-dose calcitriol, docetaxel-estramustine-bevacizumab, and docetaxel-thalidomide. The optimal timing of docetaxel-based chemotherapy is still unknown, as there are no prospective clinical trial data to indicate whether earlier treatment (eg, at the time of prostate-specific antigen failure) is more or less effective than later treatment (eg, in metastatic and/or symptomatic disease).

Original languageEnglish (US)
Pages (from-to)3-7
Number of pages5
Issue number5 SUPPL.
StatePublished - May 2005
Externally publishedYes

ASJC Scopus subject areas

  • Urology


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