The corticotropin-releasing hormone stimulation test in chronic schizophrenia

A. Roy, D. Pickar, A. Doran, O. Wolkowitz, W. Gallucci, G. Chrousos, P. Gold

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


During a drug-free period a group of schizophrenic subjects (N = 9) showed normal mean basal plasma ACTH and cortisol levels in association with normal plasma ACTH and cortisol responses to an infusion of corticotropin-releasing hormone (CRH). Administration of fluphenazine had no effect on basal ACTH and cortisol levels or their responses to CRH (N = 8). These data differ from those previously reported in depressed patients, who showed elevated basal cortisol values in association with a blunted ACTH response to CRH, and add to a growing body of literature which suggests that hypothalamic-pituitary-adrenal regulation is less disturbed in schizophrenia than in depression.

Original languageEnglish (US)
Pages (from-to)1393-1397
Number of pages5
JournalAmerican Journal of Psychiatry
Issue number11
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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