The coronavirus E protein: Assembly and beyond

Travis R. Ruch, Carolyn E. Machamer

Research output: Contribution to journalReview articlepeer-review

100 Scopus citations


The coronavirus E protein is a small membrane protein that has an important role in the assembly of virions. Recent studies have indicated that the E protein has functions during infection beyond assembly, including in virus egress and in the host stress response. Additionally, the E protein has ion channel activity, interacts with host proteins, and may have multiple membrane topologies. The goal of this review is to highlight the properties and functions of the E protein, and speculate on how they may be related.

Original languageEnglish (US)
Pages (from-to)363-382
Number of pages20
Issue number3
StatePublished - Mar 2012


  • Coronavirus assembly
  • Envelope protein
  • Golgi complex
  • Ion channel
  • Membrane protein topology

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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