The convergent roles of tapasin and HLA-DM in antigen presentation

Scheherazade Sadegh-Nasseri; Mingnan Chen; Kedar Narayan; Marlene Bouvier

doi:10.1016/j.it.2008.01.001

The convergent roles of tapasin and HLA-DM in antigen presentation

Scheherazade Sadegh-Nasseri, Mingnan Chen, Kedar Narayan, Marlene Bouvier

School of Medicine

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Cytotoxic and helper T cells respond to peptides derived from endogenous and exogenous sources that bind to major histocompatibility complex (MHC) class I and class II molecules and are presented on antigen-presenting cells. MHC class I and class II structures and maturation pathways have evolved to optimize antigen presentation to their respective T cells. The accessory proteins tapasin and HLA-DM (DM) crucially influence the selection of peptides that bind to the MHC molecules. We discuss here the dynamic interactions of tapasin and DM with their corresponding MHC molecules that indicate striking parallels. Utilization of a common mode of peptide selection by two different, but related, biological systems argue for its mechanistic validity.

Original language	English (US)
Pages (from-to)	141-147
Number of pages	7
Journal	Trends in Immunology
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/j.it.2008.01.001
State	Published - Mar 2008

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.it.2008.01.001

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title = "The convergent roles of tapasin and HLA-DM in antigen presentation",

abstract = "Cytotoxic and helper T cells respond to peptides derived from endogenous and exogenous sources that bind to major histocompatibility complex (MHC) class I and class II molecules and are presented on antigen-presenting cells. MHC class I and class II structures and maturation pathways have evolved to optimize antigen presentation to their respective T cells. The accessory proteins tapasin and HLA-DM (DM) crucially influence the selection of peptides that bind to the MHC molecules. We discuss here the dynamic interactions of tapasin and DM with their corresponding MHC molecules that indicate striking parallels. Utilization of a common mode of peptide selection by two different, but related, biological systems argue for its mechanistic validity.",

author = "Scheherazade Sadegh-Nasseri and Mingnan Chen and Kedar Narayan and Marlene Bouvier",

note = "Funding Information: We acknowledge support from National Institutes of Health grants R01AI063764 and R01GM53549 to S.S-.N. and R01AI045070 and R56AI065943 to M.B.",

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AU - Sadegh-Nasseri, Scheherazade

AU - Chen, Mingnan

AU - Narayan, Kedar

AU - Bouvier, Marlene

N1 - Funding Information: We acknowledge support from National Institutes of Health grants R01AI063764 and R01GM53549 to S.S-.N. and R01AI045070 and R56AI065943 to M.B.

PY - 2008/3

Y1 - 2008/3

N2 - Cytotoxic and helper T cells respond to peptides derived from endogenous and exogenous sources that bind to major histocompatibility complex (MHC) class I and class II molecules and are presented on antigen-presenting cells. MHC class I and class II structures and maturation pathways have evolved to optimize antigen presentation to their respective T cells. The accessory proteins tapasin and HLA-DM (DM) crucially influence the selection of peptides that bind to the MHC molecules. We discuss here the dynamic interactions of tapasin and DM with their corresponding MHC molecules that indicate striking parallels. Utilization of a common mode of peptide selection by two different, but related, biological systems argue for its mechanistic validity.

AB - Cytotoxic and helper T cells respond to peptides derived from endogenous and exogenous sources that bind to major histocompatibility complex (MHC) class I and class II molecules and are presented on antigen-presenting cells. MHC class I and class II structures and maturation pathways have evolved to optimize antigen presentation to their respective T cells. The accessory proteins tapasin and HLA-DM (DM) crucially influence the selection of peptides that bind to the MHC molecules. We discuss here the dynamic interactions of tapasin and DM with their corresponding MHC molecules that indicate striking parallels. Utilization of a common mode of peptide selection by two different, but related, biological systems argue for its mechanistic validity.

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The convergent roles of tapasin and HLA-DM in antigen presentation

Abstract

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