The Complement System in AMD

P. Charbel Issa, N. V. Chong, H. P.N. Scholl

Research output: Chapter in Book/Report/Conference proceedingChapter


Age-related macular degeneration (AMD) is a complex disease with genetic, environmental, and demo­graphic risk factors (see previous chapters). In recent years, there has been growing evidence that the inflammatory processes, including dysregulation of the complement system, play a major role in the pathogenesis of AMD. The discovery of genetic polymorphisms in genes coding for complement proteins that affect patients’ susceptibility to AMD propelled research in establishing the complement system as a key component in the pathogenesis of AMD [1].

Original languageEnglish (US)
Title of host publicationAge-Related Macular Degeneration
PublisherSpringer Berlin Heidelberg
Number of pages12
ISBN (Electronic)9783642221071
ISBN (Print)9783642221064
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • Medicine(all)


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