The comorbidity of insomnia, chronic pain, and depression: Dopamine as a putative mechanism

Patrick H. Finan, Michael T. Smith

Research output: Contribution to journalReview articlepeer-review

156 Scopus citations


Epidemiological, cross-sectional, and prospective studies suggest that insomnia, chronic pain, and depression frequently co-occur and are mutually interacting conditions. However, the mechanisms underlying these comorbid disorders have yet to be elucidated. Overlapping mechanisms in the central nervous system suggest a common neurobiological substrate(s) may underlie the development and interplay of these disorders. We propose that the mesolimbic dopamine system is an underappreciated and attractive venue for the examination of neurobiological processes involved in the interactions, development, exacerbation, and maintenance of this symptom complex. In the present article, studies from multiple disciplines are reviewed to highlight the role of altered dopaminergic function in the promotion of arousal, pain sensitivity, and mood disturbance. We argue that studies aiming to elucidate common factors accounting for the comorbidity of insomnia, chronic pain, and depression should evaluate functioning within the mesolimbic dopaminergic system and its effect on common processes known to be dysregulated in all three disorders.

Original languageEnglish (US)
Pages (from-to)173-183
Number of pages11
JournalSleep Medicine Reviews
Issue number3
StatePublished - Jun 2013


  • Affect
  • Chronic pain
  • Depression
  • Dopamine
  • Insomnia
  • Opioids
  • Stress

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


Dive into the research topics of 'The comorbidity of insomnia, chronic pain, and depression: Dopamine as a putative mechanism'. Together they form a unique fingerprint.

Cite this